基于心内膜心肌活检组织多组学分析的心血管疾病机制研究

非冠脉阻塞性&微循环障碍型缺血性心脏病的预后及机制研究

RNA甲基化与心血管疾病

基于人工智能的多模态心血管影像定量检测与预后风险分析

Mechanism of Cardiovascular Disease Based on Multiomics Analysis of Endomyocardial Biopsy Tissue

Mechanism and Prognosis of Ischemia and No Obstructive Coronary Artery Disease & Coronary Microcirculatory Diseases

RNA Methylation in Cardiovascular Disease

Quantitative Detection and Prognostic Analysis of Multimodal Cardiovascular Images based on Artificial Intelligence

附属第十人民医院心内科主任、内科学教研室主任、内科规培基地主任。中华医学会心血管病学分会动粥学组委员，中国医师学会心血管医师分会动粥学组委员，中国医师协会介入医师分会青年委员，中国医疗保健国际交流促进会胸痛分会青年委员，海峡两岸医药卫生交流协会心血管专业委员会委员，上海市医师学会心血管内科医师分会委员兼秘书，上海市卒中学会心血管内科分会常务委员，上海市医学会心血管病学专业委员会心脏重症监护学组组员，上海市胸痛中心联盟专业委员，中国医师协会心内科分会会员，中国心血管疾病介入诊疗培训项目冠心病介入导师，国家及上海自然科学基金评审专家，医师规范化培训结业考试考官。

Director of Department of Cardiology of Shanghai Tenth People’s Hospital, Member of Atherosclerosis and Coronary Heart Disease Group of the 10th and 11th Committees of the Cardiovascular Society of the Chinese Medical Association, Young Member of Chest Pain Branch of the International Association for the Promotion of Medical Care, Professional Member of Shanghai Chest Pain Center Alliance, China Member of Cardiology Branch of Medical Association, Instructor of Coronary Intervention in China Cardiovascular Intervention Training Project, Assessment Expert of National Natural Science Foundation of China and Shanghai Natural Science Foundation, Examiner of Shanghai Resident Standardized Training Completion Examination

科研课题

国家自然科学基金委员会，面上项目，82170521，基于易损斑块多源异构特征融合的心血管不良事件风险预测模型研究，2022/01-2025/12，55万，在研，主持

国家自然科学基金委员会，面上项目，81570436，Oncostatin M在肾动脉狭窄加速动脉粥样硬化中的作用及机制研究，2016/01-2019/12，68.4万，结题，主持

上海申康医院发展中心，市级医院诊疗技术推广及优化管理项目，SHDC12024120，基于无创冠脉造影微血管阻力指数的冠脉微循环障碍创新临床诊断体系应用与推广，2024/06-2027/05，30万，在研，主持

上海市科委，上海市自然科学基金，环状RNA circRic8b通过HuR-SIRT1轴参与心肌细胞凋亡在缺血再灌注损伤中的作用及机制研究，21ZR1449500，20万元，2021.7～2024.6，在研，主持

上海市科委，上海市自然科学基金，11ZR1428200，microRNA调控Gelsolin参与心梗后心肌重塑的机制研究，10万元，2011/3-2014/4，结题，主持

上海市科委，上海市医学引导项目基金，124119a6900，肾动脉狭窄加速性动脉粥样硬化相关炎性因子及其对心血管不良事件的预测价值， 10万元，2012/10-2015/10，结题，主持

上海市卫健委，面上项目，201640053，LncRNA TUG1在急性心肌梗死诊断及预后评判中的作用研究，2017/1- 2019/12，10万，结题，主持

西藏自治区科技厅、卫健委，自然科学基金组团式援藏医学项目，XZ2022ZR-ZY27(Z)，高原环境对冠状动脉微循环的影响及高原冠脉微循环障碍性心脏病的预后风险分析，2022/6-2024/5，14.53万，在研，主持

西藏自治区科技厅、卫健委，自然科学基金重点项目，XZ202301ZR0032G，高原肺动脉高压患者肠道微生态特征及其代谢组学机制研究，2023/1-2025/12，18.8万，在研，主持

西藏自治区日喀则市科技局，高原性心脏病患者肠道微生态特征及其代谢组学机制研究，2022/6-2025/5，20万，在研，主持

太阳成集团，中央高校基本科研业务费专项资金-人工智能领域学科交叉重点项目，22120190211，基于体视化智能建模理论的多模态心血管影像定量检测与分析研究，2019/9- 2021/9，60万，在研，主持

上海市第十人民医院，院内临床研究项目，基于caIMR诊断的微循环障碍对MINOCA患者预后评估价值的前瞻性多中心队列研究，30万元，2021/10-2024/9，在研，主持

上海市第十人民医院，研究型医师A类项目，基于心内膜心肌活检组织多组学分析的冠脉微循环障碍性疾病的特征和机制研究，30万元，2023/7-2026/6，在研，主持

上海市崇明区科委，“可持续发展科技创新行动计划”项目，CKY2021-21，心脏植入性电子器械术后患者合并房颤不同治疗策略的疗效与安全性评价，2021/4-2023/3，3万，在研，主持

上海市崇明区科委，“可持续发展科技创新行动计划”项目，CKY2020-29，崇明区冠状动脉非阻塞性心肌梗死患者的临床特征、诊疗现状及预后分析，2020/4-2022/3，3万，在研，主持

上海市崇明区科委，“可持续发展科技创新行动计划”项目，CKY2017-16，崇明心肌梗死基层胸痛中心救治模式的建立，2017/4-2019/3，3万，结题，主持

上海市崇明区科委，“可持续发展科技创新行动计划”项目，CKY2018-18，崇明区早发急性心肌梗死患者家族性高胆固醇血症患病率及诊疗现状研究，2018/4-2020/3，3万，结题，主持

太阳成集团，优秀青年人才培养行动计划，2009KJ011，1501219024，心梗后心肌重塑过程中miRNA表达特征， 2009/10-2012/10，2万元，结题，主持

上海市第十人民医院，350项目：IVUS/OCT/FFR优化复杂冠脉病变PCI治疗， 2017/6-2019/5，3万，结题，主持

南京医科大学，教育研究项目：反转课堂模式在MBBS心脏病学教学中的运用评价，2019/1-2021/12，重点自筹，结题，主持

上海市第十人民医院，2012院优秀学术骨干培养计划，12XSGG103，Oncostatin M在肾动脉狭窄加速性动脉粥样硬化中的作用及机制，10万元，2012/7-2014/6，结题，主持

上海市第十人民医院，院内科普培育项目，修“心”养性，远离伤“心”事——心血管病预防和康复知识的科学普及，0.3万元，2021/8-2022/7，在研，主持

太阳成集团附属十院临床太阳集团电子游戏，教学课题，反转课堂联合情景模拟模式在MBBS心脏病学教学中的运用评价， 2022/1-2023/12，0.8万元，在研，主持

PROJECT

The National Natural Science Foundation of China, 82170521，Construction of Risk Prediction Model for Major Adverse Cardiovascular Events Based on Multi-modal Heterogeneous Feature Fusion of Vulnerable Plaques. from 2022/01 to 2025/12, 550,000.

The National Natural Science Foundation of China, 81570436，The role and mechanism of Oncostatin M in accelerating atherosclerosis of renal artery stenosis, from 2016/01 to 2019/12, 684,000.

Shanghai Science and Technology Commission, Shanghai Natural Science Foundation, Role and mechanism of circular RNA circric8b in cardiomyocyte apoptosis in ischemia-reperfusion injury through hur-sirt1 axis. 21ZR1449500, 2021.07-2024.06, 200,000.

Shanghai Science and Technology Commission, Shanghai Natural Science Foundation, microRNA regulates Gelsolin's involvement in the mechanism of myocardial remodeling after myocardial infarction. Head, 11ZR1428200, March 2011-April 2014. 100,000.

Shanghai Science Committee, Shanghai Medical Guidance Project Fund, Inflammatory Factors Related to Accelerated Atherosclerosis of Renal Artery Stenosis and Their Predictive Value for Cardiovascular Adverse Events, Head, 124119a6900, 2012.10-2015.10, 100,000.

Shanghai Health Planning Commission, 20160053, The Role of LncRNA TUG1 in the Diagnosis and Prognosis of Acute Myocardial Infarction, 2017/1-2019/12, 100,000

Tibet Autonomous Region Department of Science and Technology, Health Commission, Natural Science Foundation Group Aid Tibet Medical Project, XZ2022ZR-ZY27 (Z), Impact of High Altitude Environment on Coronary Microcirculation and Prognostic Risk Analysis of High Altitude Coronary Microcirculatory Disorder Heart Disease, June 2022 to May 2024, 145300

Department of Science and Technology, Health Commission of Tibet Autonomous Region, Key Project of Natural Science Foundation, XZ202301ZR0032G, Study on Intestinal Microecological Characteristics and Metabolomics Mechanisms of Patients with High Altitude Pulmonary Hypertension, January 2023- December 2025, 188000

Shigatse City Science and Technology Bureau of Tibet Autonomous Region, Study on the gut microbiota characteristics and metabolomics mechanisms of patients with high altitude heart disease, June 2022- May 2025, 200000

Interdisciplinary Key Item in Artificial Intelligence of Tongji University, 22120190211, Quantitative Detection and Analysis of Multimodal Cardiovascular Images Based on the Theory of Stereo Visual Intelligent Modeling, 2019/9-2021/9, 600,000.

Hospital Clinical Research Project: Prospective multicenter cohort study on the prognostic value of microcirculation dysfunction diagnosed by caIMR in MINOCA patients. 2021/10-2024/09, 300,000.

Shanghai 10th People's Hospital, Research Physician Class A Project, Characteristics and Mechanisms of Coronary Microcirculatory Disorders Based on Multiomics Analysis of Endomyocardial Biopsy Tissue, July 2023 to June 2026, 300000.

The project of "Action Plan for Sustainable Development of Science and Technology Innovation" in Chongming District, Shanghai, CKY2017-16, the establishment of the treatment model of Chongming Basic-level Chest Pain Center for Myocardial Infarction, 2017/4-2019/3, 30,000.

The project of "Action Plan for Sustainable Development of Science and Technology Innovation" in Chongming District, Shanghai, CKY2018-18, the prevalence and diagnosis of familial hypercholesterolemia in patients with early-onset acute myocardial infarction in Chongming District, 2018/4-2020/3, 30,000.

Hospital 350 Project: IVUS/OCT/FFR Optimized PCI Treatment for Complex Coronary Diseases, 2017/6-2019/5, 50,000.

Hospital Teaching Projects: Evaluation of the Application of Reverse Classroom Model in MBBS Cardiology Teaching, 2018/1-2019/12, 10,000

Tongji University Outstanding Youth Talents Training Action Plan, Characteristics of MicroRNAs Expression in Myocardial Remodeling after Myocardial Infarction, Director, 2009 KJ011, 1501219024, 2009.10-2012.10, 20,000.

The role and mechanism of Oncostatin M in accelerating atherosclerosis of renal artery stenosis, responsible person, 12XSGG103, 2012.7-2014.6, 100,000.

发表文章

Chen L, Sang C, Wu Y, Chen W, Ren Y, Che W, Lu Y. Coronary Angiography-Derived Index of Microcirculatory Resistance Associated With New-Onset Atrial Fibrillation in Patients With STEMI. Can J Cardiol. 2024 Mar;40(3):434-443. doi: 10.1016/j.cjca.2023.10.025. Epub 2023 Nov 7. PMID: 37940088. (共通 IF:5.8, JCR:Q1)

Zhang W, Liu L, Yin G, Mohammed AQ, Xiang L, Lv X, Shi T, Galip J, Wang C, Mohammed AA, Mareai RM, Yu F, Abdu FA, Che W. Triglyceride-glucose index is associated with myocardial ischemia and poor prognosis in patients with ischemia and no obstructive coronary artery disease. Cardiovasc Diabetol. 2024 May 31;23(1):187. doi: 10.1186/s12933-024-02230-1. PMID: 38822373; PMCID: PMC11140859.(共通 IF:8.5, JCR: Q1)

Alifu J, Xiang L, Zhang W, Qi P, Chen H, Liu L, Yin G, Mohammed AQ, Lv X, Shi T, Abdu FA, Che W. Association between the atherogenic index of plasma and adverse long-term prognosis in patients diagnosed with chronic coronary syndrome. Cardiovasc Diabetol. 2023 Sep 21;22(1):255. doi: 10.1186/s12933-023-01989-z. PMID: 37735427; PMCID: PMC10515024. (共通 IF:9.3, JCR:Q1)

Mohammed AA, Zhang H, Li S, Liu L, Mareai RM, Xu Y, Abdu FA, Che W. Prognostic value of coronary microvascular dysfunction in patients with aortic stenosis and nonobstructed coronary arteries. J Cardiovasc Med (Hagerstown). 2023 Dec 1;24(12):891-899. doi: 10.2459/JCM.0000000000001561. Epub 2023 Nov 3. PMID: 37942790. (共通 IF: 3, JCR:Q2)

Lv X, Wang C, Liu L, Yin G, Zhang W, Abdu FA, Shi T, Zhang Q, Che W. Screening and verifying the mutations in the LDLR and APOB genes in a Chinese family with familial hypercholesterolemia. Lipids Health Dis. 2023 Oct 18;22(1):175. doi: 10.1186/s12944-023-01935-8. PMID: 37853441; PMCID: PMC10585857. (共通 IF:4.5, JCR:Q2)

Mohammed AQ, Abdu FA, Su Y, Liu L, Yin G, Feng Y, Zhang W, Xu Y, Xu D, Che W. Prognostic Significance of Coronary Microvascular Dysfunction in Patients With Heart Failure With Preserved Ejection Fraction. Can J Cardiol. 2023 Apr 20:S0828-282X(23)00312-4. doi: 10.1016/j.cjca.2023.04.011. Epub ahead of print. PMID: 37086837. (通讯 IF:6.2)

Zhang W, Liu L, Chen H, Li S, Wan M, Mohammed AQ, Xu B, Yin G, Lv X, Shi T, Galip J, Mohammed AA, Mareai RM, Xu Y, Abdu FA, Che W. Association between the triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome. Cardiovasc Diabetol. 2023 May 13;22(1):113. doi: 10.1186/s12933-023-01846-z. PMID:37179333; PMCID: PMC10183136. (通讯 IF:9.3)

Abdu, F.A., J. Galip, P. Qi, W. Zhang, A.Q. Mohammed, L. Liu, G. Yin, A.A. Mohammed, R.M. Mareai, R. Jiang, Y. Xu,W. Che: Association of stress hyperglycemia ratio and poor long-term prognosis in patients with myocardial infarction with non-obstructive coronary arteries. Cardiovasc Diabetol. 2023; 22(1):11. (通讯 IF:9.3)

Mohammed AA, Zhang H, Abdu FA, Liu L, Singh S, Lv X, Shi T, Mareai RM, Mohammed AQ, Yin G, Zhang W, Xu Y, Che W. Effect of nonobstructive coronary stenosis on coronary microvascular dysfunction and long-term outcomes in patients with INOCA. Clin Cardiol. 2022 Dec 25. doi: 10.1002/clc.23962. Epub ahead of print. PMID: 36567512. (通讯 IF:2.7)

Mareai RM, Mohammed AQ, Zhang H, Liu L, Zhang W, Mohammed AA, Yin G, Lv X, Xu Y, Abdu FA, Che W. Prognostic implication of coronary slow flow assessed by cTFC in patients with myocardial infarction with Non-obstructive coronary arteries. Eur J Intern Med. 2022 Dec 1:S0953-6205(22)00417-4. doi: 10.1016/j.ejim.2022.11.026. Epub ahead of print. PMID: 36464551. (通讯 IF:8.0)

Zhang W, Singh S, Liu L, Mohammed AQ, Yin G, Xu S, Lv X, Shi T, Feng C, Jiang R, Mohammed AA, Mareai RM, Xu Y, Yu X, Abdu FA, Che W. Prognostic value of coronary microvascular dysfunction assessed by coronary angiography-derived index of microcirculatory resistance in diabetic patients with chronic coronary syndrome. Cardiovasc Diabetol. 2022 Oct 29;21(1):222. doi: 10.1186/s12933-022-01653-y. PMID: 36309724; PMCID: PMC9618191. (通讯 IF:9.3)

Zhang H, Che W, Shi K, Huang Y, Xu C, Fei M, Fan X, Zhang J, Hu X, Hu F, Qin S, Zhang X, Huang Q, Yu F. FT4/FT3 ratio: A novel biomarker predicts coronary microvascular dysfunction (CMD) in euthyroid INOCA patients. Front Endocrinol (Lausanne). 2022 Sep 15;13:1021326. doi: 10.3389/fendo.2022.1021326. PMID: 36187090; PMCID: PMC9520241. (共一 IF:6.055)

Mohammed AA, Liu L, Mareai RM, Mohammed AQ, Yin G, Singh S, Xu Y, Abdu FA, Che W. Combination of White Blood Cell Count to Mean Platelet Volume Ratio and Neutrophil-to-Platelet Ratio Predicts Long-Term Adverse Events in Patients with MINOCA. Mediators Inflamm. 2022 Aug 16;2022:5642406. doi: 10.1155/2022/5642406. PMID: 36016662; PMCID: PMC9398882. (通讯 IF:4.529)

Feng C, Abdu FA, Mohammed AQ, Zhang W, Liu L, Yin G, Feng Y, Mohammed AA, Mareai RM, Lv X, Shi T, Xu Y, Yu X, Che W. Prognostic impact of coronary microvascular dysfunction assessed by caIMR in overweight with chronic coronary syndrome patients. Front Endocrinol (Lausanne). 2022 Aug 10;13:922264. doi: 10.3389/fendo.2022.922264. PMID: 36034462; PMCID: PMC9399838. (通讯 IF:6.055)

Liu L, Dai N, Yin G, Zhang W, Mohammed AQ, Xu S, Lv X, Shi T, Feng C,Mohammed AA, Mareai RM, Xu Y, Yu X, Abdu FA, Yu F, Che W. Prognostic value of combined coronary angiography-derived IMR and myocardial perfusion imaging by CZT SPECT in INOCA. J Nucl Cardiol. 2022 Aug 2. doi: 10.1007/s12350-022-03038-w. Epub ahead of print. PMID: 35918592 (通讯 IF:3.872)

Wang C, Wu Y, Su Y, Mao B, Luo Y, Yan Y, Hu K, Lu Y, Che W, Wan M. Elevated levels of sIL-2R, TNF-α and hs-CRP are independent risk factors for post percutaneous coronary intervention coronary slow flow in patients with non-ST segment elevation acute coronary syndrome. Int J Cardiovasc Imaging. 2022 Feb 19. doi: 10.1007/s10554-022-02529-8. Epub ahead of print. PMID: 35182256. (通讯 IF:2.316)

Yin G, Liu L, Mohammed AQ, Jiang R, Abdu FA, Che W. Association between Initial Serum Total Bilirubin and Clinical Outcome in Myocardial Infarction with Non-Obstructive Coronary Arteries. Int J Med Sci. 2022 May 27;19(6):986-992. doi: 10.7150/ijms.70833. PMID: 35813292; PMCID: PMC9254374. (通讯 IF:3.642)

Zhang H, Shi K, Fei M, Fan X, Liu L, Xu C, Qin S, Zhang J, Wang J, Zhang Y, Lv Z, Che W, Yu F. A Left Ventricular Mechanical Dyssynchrony-Based Nomogram for Predicting Major Adverse Cardiac Events Risk in Patients With Ischemia and No Obstructive Coronary Artery Disease. Front Cardiovasc Med. 2022 Mar 18;9:827231. doi: 10.3389/fcvm.2022.827231. PMID: 35369339; PMCID: PMC8971375. (通讯 IF:6.050)

Abdu FA, Mohammed AQ, Liu L, Yin G, Xu S, Mohammed AA, Mareai RM, Xu YW, Che WL. Metabolic syndrome and the risk of adverse cardiovascular events in patients with myocardial infarction with non-obstructive coronary arteries. Nutrition, Metabolism and Cardiovascular Diseases. 2022, DOI:https://doi.org/10.1016/j.numecd.2022.01.007. (通讯, IF:4.666)

Xu S, Liu L, Yin G, Mohammed AQ, Lv X, Feng C, Shi T, Abdu FA, Che W. Prognostic Significance of Uric Acid in Patients with Obstructive and Nonobstructive Coronary Artery Disease Undergoing D-SPECT. Clin Interv Aging. 2021 Nov 16;16:1955-1965. doi: 10.2147/CIA.S339600. PMID: 34815667; PMCID: PMC8605808. (通讯, IF:4.458)

Mohammed AQ, Abdu FA, Liu L, Zhang W, Yin G, Xu Y, Che W. Hyperuricemia Predicts Adverse Outcomes After Myocardial Infarction With Non-obstructive Coronary Arteries. Front Med (Lausanne). 2021 Sep 9;8:716840. doi: 10.3389/fmed.2021.716840. eCollection 2021. (通讯, IF:5.091)

Dai N, Che W, Liu L, Zhang W, Yin G, Xu B, Xu Y, Duan S, Yu H, Li C, Yao K, Huang D, Ge J.*Diagnostic Value of Angiography-Derived IMR for Coronary Microcirculation and Its Prognostic Implication After PCI. Front Cardiovasc Med. 2021 Oct 15;8:735743. doi: 10.3389/fcvm.2021.735743. eCollection 2021. (共一, IF:6.050)

Abdu FA, Mohammed AQ, Liu L, Zhang W, Yin G, Xu B, Xu S, Xu Y, Che WL*. Low Free Triiodothyronine as a Predictor of Poor Prognosis in Patients With Myocardial Infarction With Non-Obstructive Coronary Arteries. Frontiers in endocrinology. 2021 May; 12: p681978. (通讯, IF5.555)

Abdu FA, Liu L, Mohammed AQ, Yin G, Xu B, Zhang W, Xu S, Lv X, Fan R, Feng C, Shi T, Huo Y, Xu Y, Che WL*. Prognostic impact of coronary microvascular dysfunction in patients with myocardial infarction with non-obstructive coronary arteries. European journal of internal medicine.  2021 Jun. (通讯, IF:4.487)

Yin G, Abdu FA, Liu L, Xu S, Xu B, Luo Y, Lv X, Fan R, Che WL*. Prognostic Value of GRACE Risk Scores in Patients With Non-ST-Elevation Myocardial Infarction With Non-obstructive Coronary Arteries. Frontiers in cardiovascular medicine.  2021 Feb; 8: p582246. (通讯, IF: 6.050)

Mohammed AQ, Abdu FA, Liu L, Xu B, Xu S, Yin G, Feng C, Lv X, Fan R, Che WL*, Xu Y. Does Sex Influence Outcomes in Myocardial Infarction With non-obstructive Coronary Arteries (MINOCA)? Angiology. 2021 Jun. (通讯, IF:3.619)

Xu B, Liu L, Abdu FA, Yin G, Mohammed AQ, Xu S, Lv X, Fan R, Cai F, Shi T, Zhang W, Xu Y, Cai H, Yu F, Che WL*. Prognostic value of diastolic dysfunction derived from D-SPECT in coronary artery disease patients with normal ejection fraction. Front Cardiovasc Med. 2021 Jun. (通讯，IF=6.050)

Zhang BC, Wang WN, Xiao YT, Xiao SX, Chen SC, Chen SR, Xu GW, Che WL*. Cross-Subject Seizure Detection in EEGs Using Deep Transfer Learning. Comput Math Methods Med. 2020 May 8;2020:7902072. doi: 10.1155/2020/7902072. (通讯，IF:2.238)

Abdu FA, Liu L, Mohammed AQ, Xu B, Yin G, Xu S, Xu Y, Che WL*. Effect of Secondary Prevention Medication on the Prognosis in Patients With Myocardial Infarction With Nonobstructive Coronary Artery Disease. J Cardiovasc Pharmacol. 2020 Dec;76(6):678-683. (通讯，IF:3.105)

Xu B, Abdu FA, Liu L, Mohammed AQ, Yin G, Luo Y, Xu S, Lv X, Fan R, Che WL*. Clinical Outcomes and Predictors of ST-Elevation Versus Non-ST-Elevation Myocardial Infarction with Non-Obstructive Coronary Arteries. Am J Med Sci. 2020 Dec;360(6):686-692. (通讯，IF:2.378)

Zhang GK, Luo JH, Han LT, Lu ZY, Hua R, Chen JQ, Che WL*. A Dynamic Multi-scale Network For EEG Signal Classification. Front. Neurosci. doi: 10.3389/fnins.2021.578255 . (通讯，IF:4.677）

Zhang YQ, Chen JL, Chen YX, Chen YY, Li DH, Yang L, Su J, Huang X, Che WL*. An Investigation of Deep Learning Models for EEG-based Emotion Recognition. Front Neurosci. 2020 Dec 23;14:622759. doi: 10.3389/fnins.2020.622759. (通讯，IF:4.677)

Zhang GK, Yang L, Li BY, Lu YW, Liu QY, Zhao W, Ren TH, Zhou JS, Wang SH, Che WL *. A new Pulse Coupled Neural Network (PCNN) for Brain Medical Image Fusion empowered by Shuffled Frog Leaping. Front. Neurosci. 2020 Nov 17;14:870. doi: 10.3389/fnins.2020.00870. (通讯，IF:4.677)

Liu L, Abdu FA, Yin G, Xu B, Mohammed AQ, Xu S, Lv X, Luo Y, Zu L, Yang C, Zhang Z, Zhou X, Cai H, Lv Z, Xu Y, Che WL*. Prognostic value of myocardial perfusion imaging with D-SPECT camera in patients with ischemia and no obstructive coronary artery disease (INOCA). J Nucl Cardiol. 2020 Sep 30. doi:10.1007/s12350-020-02252-8. (通讯，IF:5.952)

Abdu FA, Liu L, Mohammed AQ, Luo Y, Xu S, Auckle R, Xu Y, Che WL*. Myocardial infarction with non-obstructive coronary arteries (MINOCA) in Chinese patients:Clinical features, treatment and 1 year follow-up. Int J Cardiol. 2019 Jul 15;287:27-31. (通讯，IF:3.471)

Xu GW, Shen XA, Chen SR, Zong YS, Zhang CY, Yue HY, Liu M, Chen F, Che WL*. A Deep Transfer Convolutional Neural Network Framework for EEG Signal Classification. IEEE Access. 2019; 7(1):112767-112776.(通讯，IF:4.098)

Huang CX, Lan YS, Chen SR, Liu Q, Luo X, Xu GW, Zhou W, Lin F, Peng YH, Ng Eddie Y. K.; Cheng YQ, Zeng NY*, Zhang GK*, Che WL*. Patient-Specific Coronary Artery 3D Printing Based on Intravascular Optical Coherence Tomography and Coronary Angiography. COMPLEXITY, 2019, 2019: 5712594. (通讯，IF:2.591)

Xu GW, Lan YS, Zhou W, Huang CX*, Li WB, Zhang W, Zhang GK, Ng E. Y. K.; Cheng YQ, Peng YH*, Che WL*. An IoT-Based Framework of Webvr Visualization for Medical Big Data in Connected Health. IEEE ACCESS, 2019 冬季, 7: 173866-173874. (通讯，IF:4.098)

Tang JJ, Lan YS, Chen SR, Zhong YS, Huang CX, Peng YH, Liu QY*, Cheng YQ*, Chen F*, Che WL*. Lumen Contour Segmentation in IVOCT Based on N-type CNN. IEEE Access, 2019, 7: 135573-135581. (通讯，IF:4.098)

Lan YS, Zhou YH, Lu YW, Wang H, Liu Q, NG E.Y.K., Peng YH, Hao YT, Liu QY, Chen F, Chen Y, Che WL*. A Nine Months Follow-up Study of Hemodynamic Effect on Bioabsorbable Coronary Stent Implantation. IEEE Access. 2019; 7(1): 112564-112571. (通讯，IF:4.098)

Lan YS, Ding YM, Luo X, Zhang YZ, Huang CX, Huang WH, Zhou XZ, Su J, Peng YQ, Wang ZC, Cheng YQ, Che WL*. A Clustering based Transfer Function for Volume Rendering Using Gray-Gradient Mode Histogram. IEEE Access. 2019;7:80737-80747.(通讯，IF:4.098)

Liu L, Zhao D, Zhang J, Yang H, Abdu FA, Guo R, Li S, Tang K, Li H, Che W*, Xu Y. Impact of Stable Coronary Artery Disease on the Efficacy of Cryoballoon Ablation for the Atrial Fibrillation. Am J Med Sci. 2019 Sep;358(3):204-211. (通讯，IF:1.911)

Jiang S, Guo C, Zhang W, Che W*, Zhang J, Zhuang S, Wang Y, Zhang Y, Liu B. The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation. Front Genet. 2019 Jun 13;10:526. doi: 10.3389/fgene.2019.00526. (共同第一，IF:3.517)

Huang C, Tian G, Lan Y, Peng Y, Ng EYK, Hao Y, Cheng Y, Che WL*. A New Pulse Coupled Neural Network (PCNN) for Brain Medical Image Fusion Empowered by Shuffled Frog Leaping Algorithm. Front Neurosci. 2019 Mar 20;13:210. doi: 10.3389/fnins.2019.00210. (通讯，IF:3.648)

Mohammed AQ, Auckle R, Li HL, Xu SL, Liu L, Zhao DD, Che WL*. Pegylated Interferon-α Plus Ribavirin Therapy Improves Left Ventricular Diastolic Dysfunction in Patients With Chronic Hepatitis C Attaining Sustained Virological Response. Am J Med Sci. 2018;355(6):566-572. (通讯，IF: 1.962)

Auckle R, Su B, Li H, Xu S, Xie M, Song Y, Abdul Quddus M, Xu Y, Liu B, Che WL*. Familial hypercholesterolemia in Chinese patients with premature ST-segment-elevation myocardial infarction: Prevalence, lipid management and 1-year follow-up. PLoS One. 2017;12(10):e0186815. (通讯，IF: 2.766)

Auckle R, Xu SL, Li HL, Mohammed AQ, Xie M, Su B, Liu B, Che WL*. Association of matrix-metalloproteinase-9 with left ventricular diastolic dysfunction in patients with hepatitis C virus infection.Int J Clin Exp Med. 2018; 11(2): 989-995. (通讯，IF: 0.181)

Huang C, Shan X, Lan Y, Liu L, Cai H, Che WL*, Hao Y, Cheng Y, Peng Y*. A Hybrid Active Contour Segmentation Method for Myocardial D-SPECT Images. IEEE Access. 2018; 6(1): 39334-39343. (共同通讯，IF: 4.098)

Che WL, Liu WL, Wei YD, Xu YW, Hou L, Matsumori A, Hu DY*. Increased serum N-terminal pro-B-type natriuretic peptide and left ventricle diastolic dysfunction in patients with hepatitis C virus infection. Journal of Viral Hepatitis. 2012; 19(5): 327-331. (第一，IF: 4.088)

Che WL, Zhang BC, Liu WL, Wei YD, Xu YW*, Hu DY*. Association between high-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in Patients with Hepatitis C Virus Infection. Mediators of Inflammation. 2012;2012:730923. doi: 10.1155/2012/730923. (第一，IF: 3.263)

Che WL*, Liu B, Nie F, Wei Y, Li W, Chen W, Xu Y*. Association of TNF-α with leftventricular diastolic dysfunction in patients with hepatitis C virus infection. Int J Cardiol. 2013;168(3):2903-2904.. (第一，IF: 5.509)

Liu B, Che WL(co-first author), Xue JS, Zheng CZ, Tang K, Zhang JY, Wen J, Xu YW*. SIRT4 Prevents Hypoxia-Induced Apoptosis in H9c2. Cardiomyoblast Cells. Cellular Physiology and Biochemistry. 2013;32(3):655-662. (共一，IF: 3.415)

Liu B, Che WL(co-first author), Yan HW, Zhu WD, Wang HB*. Effects of Rosuvastatin vs. Simvastatin/ ezetimibe on Arterial Wall Stiffness in Patients with Coronary Artery Disease. Internal medicine. 2013;52(24):2715-2719. (共一，IF: 0.94)

Liu B, Che WL(co-first author), Zheng C, et al. SIRT5: a safeguard against oxidative stress-induced apoptosis in cardiomyocytes. Cell Physiol Biochem. 2013;32(4):1050-1059. (共一，IF: 3.415)