ARVO 会员，中国生物化学与分子生物学学会会员会员ARVO member，Chinese society of Biochemistry and molecular biology （CSBMB）member
课题
1.国家自然科学基金面上：GMFB调控星形胶质细胞CARM1/PPARG通路改善损伤轴突再髓鞘化的机制研究（82471073）2025.1-2028.12
文章
1.Sun W, Wang J, Liu C, Gao F, Ou Q, Tian H, Xu J, Zhang J, Li J, Xu J, Jia S, Zhang J, Xu G, Huang J, Jin C, Lu L. SUMOylation of GMFB regulates its stability and function in retinal pigment epithelial cells under hyperglycemia. Int J Biol Macromol. 2024;268(Pt2):131678. doi: 10.1016/j.ijbiomac.2024.131678.
2. Zhu T, Li Y, Zhu L, Xu J, Feng Z, Chen H, Shi S, Liu C, Ou Q, Gao F, Zhang J, Jin C, Xu J, Li J, Zhang J, Bi Y, Xu GT, Wang J, Tian H, Lu L*.GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model.Glia. 2024 Mar;72(3):504-528. doi: 10.1002/glia.24486. .
3.Shi S, Gu H, Xu J, Sun W, Liu C, Zhu T, Wang J, Gao F, Zhang J, Ou Q, Jin C, Xu J, Chen H, Li J, Xu G, Tian H, Lu L. Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity. Exp Mol Med. 2023 ;55(5):898-909. doi: 10.1038/s12276-023-00980-8.
3.Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L.Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.Redox Biol. 2022 Jun;52:102292. doi: 10.1016/j.redox.2022.102292.
4.Liu C, Zhu T, Zhang J, Wang J, Gao F, Ou Q, Jin C, Xu JY, Zhang J, Tian H*, Xu GT*, Lu L*.Identification of novel key molecular signatures in the pathogenesis of experimental diabetic retinopathy.IUBMB Life，2021 Nov;73(11):1307-1324. doi: 10.1002/iub.2544.
发明专利
(1)吕立夏; 徐国彤; 孙琬; 施思; 刘彩莹; 王娟; 张介平; 高芙蓉; 金彩霞; 田海滨; 徐晶莹; 欧庆健; 小分子化合物在制备治疗GMFB介导疾病的药物中的应用, 2021-7-30, 中国, 202110869322 .X
(2) 吕立夏; 徐国彤; 刘彩莹; 王娟; 张介平; 高芙蓉; 金彩霞; 田海滨; 徐晶莹; 欧庆健; 陈浩 ; 选择性自噬激活剂QX77在制备干预或治疗糖尿病视网膜病变的药物中的应用, 2023-04-28, 中国,CN202210185418.9
(3) 吕立夏 吕 ; 徐国彤 ; 视网膜色素上皮细胞上皮－间充质转换模型及其应用, 2015-8-21, 中国,2015105197059
