郑瑞娟博士主要在结核病遗传易感性和结核病的免疫发病机制方面有较系统的研究工作，利用候选基因策略和全基因组关联分析策略鉴定出多个中国汉族人群结核病易感基因，并在此基础上对结核病发病机制和靶向宿主抗结核治疗开展了深入研究 。主持国家自然科学基金项目2项，上海市自然科学基金，上海市卫生局青年基金各1项，参与国家自然科学基金重点项目，国家“十一五”、“十二五”、“973”专项等多个项目。在《Nature Commun》, 《J Infect Dis》等期刊发表论文30多篇，其中第一作者/通讯作者论文10篇，作为第一发明人授权发明专利2项，参编专著3部。
Dr. Ruijuan Zheng has a systematic work in the genetic susceptibility of tuberculosis and the immunological pathogenesis of tuberculosis. Using candidate gene strategy and genome-wide association analysis strategy, her team has identified many susceptibility genes of tuberculosis in Chinese Han populations. On this basis, they also conduct research on pathogenesis of tuberculosis and host directed therapy for tuberculosis. Dr. Ruijuan Zheng has undertaken many projects supported by the National Natural Science Foundation of China, Science and Technology Commission of Shanghai Municipality and so on. She has published more than 30 research papers on domestic and international journals including Nature Commun and J Infect Dis. She also obtained 2 invention patents and edited three books on Tuberculosis.
Selected publications:
[1] Zheng R#, Li Z#, He F#, Liu H, Chen J, Chen J, Xie X, Zhou J, Chen H, Wu X, Wu J, Chen B, Liu Y, Cui H, Fan L, Sha W, Liu Y, Wang J, Huang X, Zhang L, Xu F, Wang J, Feng Y, Qin L, Yang H, Liu Z, Cui Z, Liu F, Chen X, Gao S, Sun S, Shi Y, Ge B. Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese. Nat Commun. 2018 Oct 4;9(1):4072；
[2]Zheng R, Liu H, Zhou Y, Yan D, Chen J, Ma D, Feng Y, Qin L, Liu F, Huang X, Wang J, Ge B. Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation. J Infect Dis. 2018 Jun 20;218(2):312-323；
[3] Liu H#, Zheng R#, Wang P#, Yang H, He X, Ji Q, Bai W, Chen H, Chen J, Peng W, Liu S, Liu Z, Ge B. IL-37 Confers Protection against Mycobacterial Infection Involving Suppressing Inflammation and Modulating T Cell Activation. PLoS One. 2017 11;12(1):e0169922；
[4] Zheng R#, Liu H#, Song P, Feng Y, Qin L, Huang X, Chen J, Yang H, Liu Z, Cui Z, Hu Z, Ge B. Epstein-Barr virus-induced gene 3 (EBI3) polymorphisms and expression are associated with susceptibility to pulmonary tuberculosis. Tuberculosis (Edinb). 2015 Jul;95(4):497-504；
[5] Zheng R, Zhu C, Guo Q, Qin L, Wang J, Lu J, Cui H, Cui Z, Ge B, Liu J, Hu Z. Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients. BMC Infect Dis. 2014，13;14:200.
