固有免疫是机体免疫防御的第一道防线，并且诱导适应性免疫等。固有免疫失衡与多种严重影响国民健康的重大疾病相关，包括感染性疾病、肿瘤、自身免疫性疾病、心脑血管病、过敏性疾病、移植排斥反应、肿瘤等。课题组长期围绕固有免疫分子功能及与相关疾病的调控机制开展了系统性研究，并取得了一系列原创性和引领性研究成果，如发现结核菌利用宿主来进行免疫逃避及固有免疫分子cGAS抑制DNA损伤修复的新功能等，在领域内产生了重要国际影响。共发表研究论文100多篇，包括以通讯作者（唯一或最后）发表了Nature (2018, 2020)、Nature Immunology (2008, 2012,2016)、Nature Microbiology (2019)、Cell Host & Microbe (2009, 2023)、Cell Research (2208, 封面)、Molecular Cell (2022)、Cell Discovery (2021)和Nature Communications (2018a, 2018b)等。申请发明专利23项，获得授权14项。完成一项抗耐药结核药物IIa临床试验，达成一项抗结核疫苗转化合作协议（里程碑付款3.075亿元）。
一、代表性研究论文：
Liu S, Guan L, Peng C, Cheng Y, Cheng H, Wang F, Ma M, Zheng R, Ji Z, Cui P, Ren Y, Li L, Shi C, Wang J, Huang X, Cai X, Qu D, Zhang H, Mao Z, Liu H, Wang P, Sha W, Yang H,* Wang L,* Ge B* (2023) Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival. Cell Host & Microbe (accepted)
Wang F#, Zhao M#, Chang B#, Zhou Y, Wu X, Ma M, Liu S, Cao Y, Zheng M, Dang Y, Xu J, Chen L, Liu T, Tang F, Ren Y, Xu Z, Mao Z, Huang K, Luo M, Li J*, Liu H*, Ge B*. (2022) Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. Molecular Cell. 82(11):2032-2049.e7.
Yang H#, Wang F#, Guo X#, Liu F#, Liu Z, Wu X, Zhao M, Ma M, Liu H, Qin H, Wang L, Tang T, Sha W, Wang Y, Chen J, Huang X, Wang J, Peng C, Zheng R, Tang F, Zhang L, Wu C, Oehlers SH, Song Z, She J, Feng H, Xie X, Ge B*. (2021) Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity. Cell Discovery 7(1):90. doi: 10.1038/s41421-021-00301-1.
Wu X#, Wu Y#, Zheng R#, Tang F, Qin L, Lai D, Zhang L, Chen L, Yan B, Yang H, Wang Y, Li F, Zhang J, Wang F, Wang L, Cao Y, Ma M, Liu Z, Chen J, Huang X, Wang J, Jin R, Wang P, Sun Q, Sha W, Lyu L, Moura-Alves P, Dorhoi A, Pei G, Zhang P, Chen J, Gao S, Randow F, Zeng G, Chen C, Ye XS*, Kaufmann SHE*, Liu H*, Ge B*. (2021) Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection. EMBO Rep. 22(7):e51678.
Zhao M#, Wang F#, Wu J#, Cheng Y, Cao Y, Wu X, Ma M, Tang F, Liu Z, Liu H*, Ge B*. (2021) cGAS is a micronucleophagy receptor for the clearance of micronuclei. Autophagy. 22:1-17.
Wang L#, Wu J#, Li J#, Yang H, Tang T, Liang H, Zuo M, Wang J, Liu H, Liu F, Chen J, Liu Z, Wang Y, Peng C, Wu X, Zheng R, Huang X, Ran Y, Rao Z*, Ge B* (2020) Host-mediated ubiquitination of a mycobacterial protein suppresses immunity. Nature 577, 682-688. (Highlighted by Cell Host & Microbe, Science Bulletin)
Wang L#, Liu Z#, Wang J, Liu H, Tang T, Li H, Yang H, Qin L, Ma D, Chen J, Liu F, Zheng R, Song P, Zhou Y, Cui Z, Wu X, Wu J, Huang X, Wu C, Chen X, Zeng G, Ge B*. (2019) Oxidization of TGF β-activated kinase (TAK1) by MPT53 is required for immunity to Mycobacterium tuberculosis. Nature Microbiology 4, 1378–1388
Wang L, Zhou Y, Chen Z, Sun L, Wu J, Li H, Liu F, Wang F, Yang C, Yang J, Leng Q, Zhang Q, Xu A, Shen L, Sun J, Wu D, Fang C, Lu H*, Yan D*, Ge B*. (2019) PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1. Nature Communications 14;10(1):746.
Liu H#, Zhang H#, Wu X#, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T., Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SH, Chen C, Mao Z * & Ge B*. (2018) Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature 563, 131–136. (Highlighted by Nature Reviews Molecular Cell Biology, Cancer Discovery and Science Signaling)
Zheng R#, Li Z#, He F#, Liu H*, Chen J, Cheng J, Xie X, Zhou J, Chen H, Wu X, Wu J, Chen B, Liu Y, Cui H, Fan L, Sha W, Liu Y, Wang J, Huang C, Zheng L, Xu F, Wang J,, Feng Y, Qin L, Yang H, Liu Z, Cui Z, Liu F, Chen X, Gao S, Sun S*, Shi Y* & Ge B*. (2018) Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese. Nature Communications 9, 4295.
Liu F#, Chen J#, Zhou Y, Liu H, Li H, Wang P, a Liu Z, Zheng R, Wang L, Yang H, Cui Z, Huang X, Wang J, Sha W, Xiao H & Ge B*. (2018) MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy. Nature Communications 9, 4072-
Zhou Y, He C, Yan D, Liu F, Liu H, Chen J, Cao T, Zuo M, Wang P, Ge Y, Lu H, Tong Q, Qin C, Deng Y, Ge B*. (2016) The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3. Nature Immunology 17(4):397-405.
Yan DP, Wang X., Li-Jun Luo LJ, Xuetao Cao X. and Ge B.* (2012) Inhibition of toll-like receptor signaling by an ITIM-containing bacterial protein. Nature Immunology, 13(11):1063-71
Kong L, Zhang H, Qin L, Zhuang ZH, Sun L, Yu MC, Zhu J, Chen Z. Wang ZG* and Ge B* 2009 An essential role for RIG-I in Toll-like receptor-mediated phagocytosis. Cell Host & Microbe 6(2):150-161. (Cited by “Faculty of 1000 Biology, Highlighted by Nature)
Yu MC, Su LL, Zou L, Liu Y, Wu N, Kong L, Zhuang ZH, Sun L, Liu HP, Hu JH, Li D, Strominger JL, Zang JW, Pei G*, Ge B.* (2008) An essential function for β-arrestin 2 in the inhibitory signaling of Natural Killer cells. Nature Immunology, 9(8):898-907. (Commented in Nature Immunology, Highlighted by Nature)
Kong L, Ge B*. (2008) MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis. Cell Research. 18(7):745-55 (Cover Story)
二、已授权发明专利：
戈宝学,郑瑞娟,唐神结,刘海鹏,陈建霞. 一种检测结核易感性的检测标靶、引物及试剂 ZL201210060910.X
秦莲花，戈宝学，胡忠义，王洁，陆俊梅. 一种结核分枝杆菌的耐药新基因及其应用 ZL201310398783.9
戈宝学，王琳，严大鹏. 化合物调节TAK1活性的方法及该化合物用于治疗手足口病的应用 ZL201410822283.8
戈宝学，杨华，刘忠华，郑瑞娟，黄晓辰. 结核病检测多肽及其应用ZL201510673889.4
戈宝学，杨华，刘忠华，郑瑞娟，黄晓辰. 一种结核病检测多肽及其应用 ZL201510673936.5
戈宝学，郑瑞娟 一种用于治疗结核患者的组合物 ZL201510719291.4
戈宝学，陈建霞，刘峰，刘海鹏，李蒿蒿，王菲，刘忠华，唐芬，黄晓辰，王洁. C24H24N6O2S3在制备抗结核菌药物中的用途 ZL201811369301.6
戈宝学、杨华、刘忠华、黄晓辰、王洁. 一种用于结核病诊断的标记物及其应用 ZL201910817382.X
戈宝学、刘海鹏、秦莲花、赖德恬、吴向阳、郑瑞娟. 一种结核杆菌阿拉伯半乳聚糖适配子及其应用 ZL201910846950.9
戈宝学，陈建霞、刘峰，李蒿蒿，刘海鹏，郑瑞娟，刘忠华. 塞来昔布衍生物OSU-03012在制备抗结核菌药物中的应用 ZL201811369301.6
戈宝学,杨华,王菲,郭欣娅. 二羟基苯甲酰胺衍生物在制备SerC抑制剂和抗结核药物中的应用 ZL202110401527.5
戈宝学,杨华,王菲,郭欣娅. 肌苷在制备预防和治疗结核病药物中的应用 ZL202110996941.5
戈宝学,杨华,王菲,郭欣娅. 甘油磷酸胆碱在制备预防和治疗结核病药物中的应用 ZL202110996943.4
三、承担科研项目：
1.国家自然科学基金科学中心项目，2022.1-2026.12, “病原体与宿主基础科学中心”。子课题负责人。
2. 国家基金委重点项目，2021.1-2025.12，“糖尿病并发结核病的代谢免疫特征及调控机制研究”。项目负责人。
3. 国家基金委重大计划集成项目，2019.1-2021.12，“肉芽肿形成的肺部区域免疫特征及调控机制研究”。项目负责人。
4. 国家重点研发计划项目蛋白质专项，2017.7-2022.6，“重要病原菌感染与致病过程中蛋白质机器的功能机制”。项目负责人，综合绩效评价评分91.89（A档）。
5. 国家基金委重点项目，2014.1-2018.12，“Notch4在结核病中对免疫细胞功能的影响及机制研究”，290万。项目负责人。
6. 科技部973项目（2012CB518700），2012.1-2016.12，“重要病原菌与宿主相互作用分子机制的研究”。项目负责人。结题优秀。
