聚焦衰老与心血管疾病，开展细胞与基因治疗的基础与转化研究，主要包括：
1. 基于干细胞与组织工程的器官修复；
2. 细胞外囊泡的信息递送与工程化改造；
3. 单细胞组学新技术；
Interdisciplinary studies for aging and cardiovascular disease, including:
1, Stem cell and tissue engineering;
2, Extracellular vesicle；
3, Single-cell omics
国家自然科学基金通讯评审专家（国家基金委，2020-今）
上海市科学技术奖评审专家（上海市科委，2019-今）
安徽省重点研发计划评审专家（安徽省科技厅，2021-今）
江西省自然科学基金重点项目评审专家（江西省科技厅，2020-今）
云南省基础研究计划评审专家（云南省科技厅，2024-今）
黑龙江省自然科学基金评审专家（黑龙江省科技厅，2024-今）
"SCI 期刊审稿人" (ACS Nano, Theranostics, Stem cells等);
近年以通讯/第一作者（含共同）于Science Advances、Science Bulletin、Protein Cell（2篇）、Theranostics（2篇）、ATVB（2篇）等高水平期刊发表SCI论文12篇，其中6篇单篇IF>10，2篇单篇IF>20，总计143；研究成果被Springer经典专业丛书《Advances in Experimental Medicine and Biology》收录；临床级干细胞培养基和单细胞蛋白组技术2项原研成果完成转化；主持国家和省部级项目6项，入选上海市东方英才计划。担任国自然评审专家以及ACS Nano等学术期刊审稿人
代表性论文：
1. Human PBMC scRNA-seq based aging clocks reveal ribosome to inflammation balance as a single cell aging hallmark and super longevity. Science Advances. 2023, 9(26): eabq7599. (IF:13.6)
2. A simple, rapid, and practical method for single-cell proteomics based on mass-adaptive coating of synthetic peptides. Science Bulletin. 2022, 67(6): 581-584. (IF:18.9)
3. Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype. Protein Cell. 2021,12(3):192-212. (IF: 21.1)
4. Single-cell transcriptomics of cardiac progenitors reveals functional subpopulations and their cooperative crosstalk in cardiac repair. Protein Cell. 2021, 12(2):152-157. (IF: 21.1)
5. Cardio-renal Exosomes in Myocardial Infarction Serum Regulate Proangiogenic Paracrine Signaling in Adipose Mesenchymal Stem Cells. Theranostics. 2020; 10(3): 1060-1073. (IF: 12.4)
6. Coronary Serum Exosomes Derived from Patients with Myocardial Ischemia Regulate Angiogenesis through the miR-939-mediated Nitric Oxide Signaling Pathway. Theranostics. 2018; 8(8): 2079-2093. (IF: 12.4)
7. Inducible Metabolic Adaptation Promotes Mesenchymal Stem Cell Therapy for Ischemia: A Hypoxia-Induced and Glycogen-Based Energy Prestorage Strategy. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014; 34: 894-901. (IF:8.7)
8. Aldehyde Dehydrogenase-2 Is a Host Factor Required for Effective Bone Marrow Mesenchymal Stem Cell Therapy. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014; 34: 870-876. (IF: 8.7)
9. Loading Nanoceria Improves Extracellular Vesicle Membrane Integrity and Therapy to Wounds in Aged Mice. ACS Biomaterials Science & Engineering. 2023; 9(2):732-742. (IF: 5.8)
10. Extracellular vesicle: A magic lamp to treat skin aging, refractory wound, and pigmented dermatosis? Frontiers in Bioengineering and Biotechnology. 2022; 10: 1043320. (IF:5.7)
11. Aldehyde Dehydrogenase 2 Deficiency Negates Chronic Low-to-Moderate Alcohol Consumption-induced Cardioprotecion Possibly via ROS-dependent Apoptosis and RIP1/RIP3/MLKL-mediated Necroptosis. BBA Molecular Basis of Disease.2016; (16)30298-8 （IF:6.2）
12. Long Noncoding RNA: Recent Updates in Atherosclerosis. International Journal of Biological Sciences. 2016; 12: 898-910（IF:9.2）
13. Hypoxia inhibits the spontaneous calcifications of bone marrow-derived mesenchymal stem cells.
Journal of Cellular Biochemistry. 2012; 113(4): 1407-1415. (IF: 4)
