博士后 瑞典卡罗林斯卡学院(诺贝尔医学和生理学奖评审机构)
Post-doctor of Karolinska Institute, Sweden
科研教学科科长,伦理办公室主任,第三行政党支部书记
Chief of the scientific research and teaching department of the hospital,
Director of the ethics office of the hospital
多个学会委员:中国医师协会发展委员会委员,中联伦理学会委员,上海康复学会皮肤分会委员,中西医结合皮肤科分会委员等
以(共同)第一/通讯作者身份发表论文40多篇,其中9篇1区论文,且3篇论文影响因子超过10分。授权发明专利1项,申请国际专利1项。主编著作3部,副主编1部。2项科技奖项。
近年主持纵向项目:
1、基于CRISPR/Cas12a技术的皮肤真菌核酸快速检测试剂盒临床研究,22Y11905700 (上海市科委).经费30万 在研。
2、新型光刺激虾青素纳米-水凝胶对抗皮肤衰老作用及机制,2020YJZX0108(上海老龄化和妇儿健康研究专项).40万,在研。
3、基于质谱分析建立水疱性皮肤病病原微生物检测平台及其生物标记分子的筛选,SHDC12018X0(上海申康三年行动计划项目). 30万在研。
4、多肽介导紫杉醇隐形纳米粒抗黑素瘤血管生成效应研究,15ZR1436900(上海市科委).10万 结题
5、皮肤性病健康教育与健康促进,12GWZX0902(上海公共卫生重点团队建设项目). 100万 结题。
横向课题:1、化妆品和原料体外替代方法基础研究和测评 60万 在研
2 祛斑美白化妆品美白功效评价体外替代方法研究 30万 在研
主编著作:
简明甲及甲周疾病皮肤镜图谱,太阳成集团出版社,主编;
皮肤病性病健康教育与健康促进,第二军医大学出版,主编;
别让皮肤病盯上你,第二军医大学出版社,主编
简明皮肤病临床及组织病理图谱,广东科技出版社,副主编
近年发表部分文章 [(共同)第一/通讯]:
1.Thiostrepton induces oxidative stress, mitochondrial dysfunction and ferroptosis in HaCaT cells. Cellular Signalling.2024.(4.4/Q2)
2.Oroxylin A suppress LL-37 generated rosacea-like skin inffammation through the modulation of SIRT3-SOD2-NF-κB signaling pathway. International Immunopharmacology.2024 (4.8/Q1)
3.CRISPR‑based quantum dot nanobead lateral fow assay for facile detection of varicella‑zoster virus. Applied Microbiology and Biotechnology.2023 (5.0/Q2)
4.Improvement of Pruritus and Efficacy in the Early Stage of Therapy with Upadacitinib, Abrocitinib,or Dupilumab in Chinese Patients with Moderate-to-Severe Atopic Dermatitis:Prospective, Cohort, Observational Study. DERMATITIS,2023(4.8,Q1)
5.Luteolin-Loaded Nanoparticles for the Treatment of Melanoma. International Journal of Nanomedicine.2023(8/Q1)
6.Single-cell analysis of human prepuce reveals dynamic changes in gene regulation and cellular communications. BMC Genomics,2023(4.5 Q2)
7.Integrative analysis of multi-omics data for liquidbiopsy. British Journal of Cancer 2022. (Nature子刊)
8.GRNdb: decoding the gene regulatory networks in diverse human and mouse conditions. Nucleic Acids Research 2021,IF 19.61 Q1
9.Single-cell transcriptomic analysis reveals dynamic alternative splicing and gene regulatory networks among pancreatic islets SCIENCE CHINA Life Sciences 2020. IF 10.37,Q1
10.Lactate Induces Production of the tRNAHis Half to Promote B-lymphoblastic Cell Proliferation. Molecular Therapy,2020. IF 12.91 Q1
11.Comparison of samples of blister fluid and scales in the diagnosis of dermatomycosis,Mycoses,2022,6,IF:4.9
12.Bimodal size distribution immuno-quantum dots for fluorescent western blotting assay with high sensitivity and extended dynamic range. Microchimica Acta .2020. IF 6.2 Q1
13.Correlation Between Facial Skin Microbiota and Skin Barriers in a Chinese Female Population with Sensitive Skin. Infection and Drug Resistance. 2021
14.Effect of Shinkonin Against Candida albicans biofilms. Frontiers in microbiology. 2019 IF 6.06
15.Lactic Acid Downregulates Viral MicroRNA To Promote Epstein-Barr Virus-Immortalized B Lymphoblastic Cell Adhesion and Growth. J Virology.2018 IF 6.54 Q1
16.A novel delivery vector for targeted delivery of the antiangiogenic drug paclitaxel to angiogenic blood vessels: TLTYTWS-conjugated PEG–PLA nanoparticles. Journal of Nanoparticle Research, 2017
科研奖励:第四期上海市医务科技创新“星光计划”二等奖,负责人
发明专利:
1、乳酸诱导上皮样细胞分化的B淋巴细胞模型及其构建与应用