博士及博士后期间主要从事游离核酸在非侵袭性产前诊断、移植排斥和肿瘤诊断方面的研究。近年来主要从事感染性疾病的病毒分子进化与感染免疫方面的研究。已发表SCI论文27篇，主持国家自然基金面上项目1项、上海市科委课题1项、子课题2项和上海市市卫计委课题1项。
代表性论文：
1. Leung
TN, Zhang J, Lau TK, Hjelm NM, Lo YM. Maternal plasma fetal DNA as a
marker for preterm labour. Lancet 1998;352:1904-5.
2. Zhang J, Tong KL, Li PK, Chan AY, Yeung CK, Pang CC, et al. Presence of donor- and recipient-derived
DNA in cell-free urine samples of renal transplantation recipients: urinary DNA
chimerism. Clin Chem 1999;45:1741-6.
3. Lo
YM, Zhang J, Leung TN, Lau TK, Chang AM, Hjelm NM. Rapid clearance of
fetal DNA from maternal plasma. Am J Hum Genet 1999;64:218-24.
4. Lo
YM, Lau TK, Zhang J, Leung TN, Chang AM, Hjelm NM, et al. Increased
fetal DNA concentrations in the plasma of pregnant women carrying fetuses with
trisomy 21. Clin Chem 1999;45:1747-51.
5. Lo
YM, Wong IH, Zhang J, Tein MS, Ng MH, Hjelm NM. Quantitative analysis of
aberrant p16 methylation using real-time quantitative methylation-specific
polymerase chain reaction. Cancer Res 1999;59:3899-903.
6. Tang NL,
Leung TN, Zhang J, Lau TK, Lo YM. Detection of fetal-derived paternally
inherited X-chromosome polymorphisms in maternal plasma. Clin Chem
1999;45:2033-5.
7. Zhang J,
Fidler C, Murphy MF, Chamberlain PF, Sargent IL, Redman CW, et al.
Determination of fetal RhD status by maternal plasma DNA analysis. Ann N Y
Acad Sci 2000;906:153-5.
8. Leung TN, Zhang
J, Lau TK, Chan LY, Lo YM. Increased maternal plasma fetal DNA
concentrations in women who eventually develop preeclampsia. Clin Chem
2001;47:137-9.
9. Chan KC, Zhang
J(并列第一作者), Chan AT, Lei KI, Leung SF, Chan LY, et
al. Molecular characterization of circulating EBV DNA in the plasma of
nasopharyngeal carcinoma and lymphoma patients. Cancer Res 2003;63:2028-32.
10. Chan
KC, Zhang J(并列第一作者), Hui AB, Wong N, Lau TK, Leung TN, et al.
Size distributions of maternal and fetal DNA in maternal plasma. Clin Chem
2004;50:88-92.
11.Shen Z, Wang G, Zhang WJ, Qian FX, Li Y, Zhang M, Gu SM, Wang MY, Lin F, Hu YW, Yuan ZH, Zhang J (通讯作者). Rotavirus infection and its genetic characterization in non-hospitalized adults with acute
gastroenteritis in Shanghai,
China. Archives of Virology, 2013, 158(8):1671-7.
12. Shen Z, Qian FX, Li Y, Hu YW, Yuan ZH, Zhang J (通讯作者). Novel Norovirus GII.4 Variant, Shanghai, China, 2012. Emerging
Infectious Diseases, 2013, 19(8):1337-9.
13., Chen ZJ, Li X, Xu L, Guan WC, Cao YS, Hu YW, Zhang J (通讯作者).
Host immunological response and factors associated with clinical outcome in
patients with the novel influenza A H7N9 infection. Clinical Microbiology and
Infection, 2014, 20(8):O493-500
14.Wang G, Shen Z, Qian FX, Li Y, Yuan ZH,
Zhang J (通讯作者). Genetic
diversity of sapovirus in non-hospitalized adults with sporadic cases of acute
gastroenteritis in Shanghai, China. Journal of Clinical Virology, 2014, 59(4):250-4.
15.Zhang
J, Shen Z, Zhu ZQ, Zhang WJ, Chen HF, Qian FX, Chen HL, Wang G, Wang MY, Hu
YW, Yuan ZH. Genotype distribution of norovirus around the emergence of Sydney
2012 and the antigenic drift of contemporary GII.4 epidemic strains. Journal of Clinical Virology, 2015, 72:95-101.
课题：
1.国家自然科学基金，诺如病毒GII.4流行株衣壳蛋白分子进化机理的研究。
2.上海市科学技术委员会，噬菌体展示技术在诺如病毒快速检测中的应用研究。
3.上海市卫计委，噬菌体展示技术在诺如病毒快速诊断中的应用。
4.上海市科学技术委员会，乙肝和梅毒等快速诊断试剂的质量对比研究（子课题负责）。
5.上海市科学技术委员会，结核菌抗体诊断试剂盒在肺内外结核的临床再评价（子课题负责）。
The earlier
research works during the PhD and postdoc were focused on the studies of cell free
nucleic acids in non-invasive prenatal diagnosis, graft rejection and tumor
diagnosis. In recent years, the research interests concern the molecular
diagnosis of infectious diseases. So far more than 20 papers have been
published in SCI. The main research works were supported by several grants including 1 from National Natural Science Foundation
of China, 1 Shanghai Science
and Technology Committee, and 1 Shanghai Municipal Commission of Health and
Family Planning.
Selected
publications:
1. Leung
TN, Zhang J, Lau TK, Hjelm NM, Lo YM. Maternal plasma fetal DNA as a
marker for preterm labour. Lancet 1998;352:1904-5.
2. Zhang J, Tong KL, Li PK, Chan AY, Yeung CK, Pang CC, et al. Presence of donor- and recipient-derived
DNA in cell-free urine samples of renal transplantation recipients: urinary DNA
chimerism. Clin Chem 1999;45:1741-6.
3. Lo
YM, Zhang J, Leung TN, Lau TK, Chang AM, Hjelm NM. Rapid clearance of
fetal DNA from maternal plasma. Am J Hum Genet 1999;64:218-24.
4. Lo
YM, Lau TK, Zhang J, Leung TN, Chang AM, Hjelm NM, et al. Increased
fetal DNA concentrations in the plasma of pregnant women carrying fetuses with
trisomy 21. Clin Chem 1999;45:1747-51.
5. Lo
YM, Wong IH, Zhang J, Tein MS, Ng MH, Hjelm NM. Quantitative analysis of
aberrant p16 methylation using real-time quantitative methylation-specific
polymerase chain reaction. Cancer Res 1999;59:3899-903.
6. Tang NL,
Leung TN, Zhang J, Lau TK, Lo YM. Detection of fetal-derived paternally
inherited X-chromosome polymorphisms in maternal plasma. Clin Chem
1999;45:2033-5.
7. Zhang J,
Fidler C, Murphy MF, Chamberlain PF, Sargent IL, Redman CW, et al.
Determination of fetal RhD status by maternal plasma DNA analysis. Ann N Y
Acad Sci 2000;906:153-5.
8. Leung TN, Zhang
J, Lau TK, Chan LY, Lo YM. Increased maternal plasma fetal DNA
concentrations in women who eventually develop preeclampsia. Clin Chem
2001;47:137-9.
9. Chan KC, Zhang
J(并列第一作者), Chan AT, Lei KI, Leung SF, Chan LY, et
al. Molecular characterization of circulating EBV DNA in the plasma of
nasopharyngeal carcinoma and lymphoma patients. Cancer Res 2003;63:2028-32.
10. Chan
KC, Zhang J(并列第一作者), Hui AB, Wong N, Lau TK, Leung TN, et al.
Size distributions of maternal and fetal DNA in maternal plasma. Clin Chem
2004;50:88-92.
11.Shen Z, Wang G, Zhang WJ, Qian FX, Li Y, Zhang M, Gu SM, Wang MY, Lin F, Hu YW, Yuan ZH, Zhang J (通讯作者). Rotavirus infection and its genetic characterization in non-hospitalized adults with acute
gastroenteritis in Shanghai,
China. Archives of Virology, 2013, 158(8):1671-7.
12. Shen Z, Qian FX, Li Y, Hu YW, Yuan ZH, Zhang J (通讯作者). Novel Norovirus GII.4 Variant, Shanghai, China, 2012. Emerging
Infectious Diseases, 2013, 19(8):1337-9.
13., Chen ZJ, Li X, Xu L, Guan WC, Cao YS, Hu YW, Zhang J (通讯作者).
Host immunological response and factors associated with clinical outcome in
patients with the novel influenza A H7N9 infection. Clinical Microbiology and
Infection, 2014, 20(8):O493-500
14.Wang G, Shen Z, Qian FX, Li Y, Yuan ZH,
Zhang J (通讯作者). Genetic
diversity of sapovirus in non-hospitalized adults with sporadic cases of acute
gastroenteritis in Shanghai, China. Journal of Clinical Virology, 2014, 59(4):250-4.
15.Zhang
J, Shen Z, Zhu ZQ, Zhang WJ, Chen HF, Qian FX, Chen HL, Wang G, Wang MY, Hu
YW, Yuan ZH. Genotype distribution of norovirus around the emergence of Sydney
2012 and the antigenic drift of contemporary GII.4 epidemic strains. Journal of Clinical Virology, 2015, 72:95-101.
Research projects:
1. National Natural Science Foundation of China，Molecular evolution of viral capsid protein in
norovirus GII.4 strains.
2. Shanghai Science and Technology Committee，The study of phage display techniques
used in the diagnosis of norovirus.
3. Shanghai Municipal Commission of Health
and Family Planning，Rapid detection of norovirus by the use of phage display techniques.
4. Shanghai Science and Technology
Committee，Comparative
study on quality of rapid diagnostic kits for hepatitis B virus and syphilis (sub-project).
5.
Shanghai Science and Technology Committee，Clinical evaluation of TB
antibody diagnostic kit in internal and external pulmonary tuberculosis (sub-project).
