我目前重点研究集中在肝胆恶性肿瘤治疗效果的优化方案选择。同时，我的基础研究致力于发现HBV相关性肝癌发展的表观遗传分子机制。目前我已获得四个国家自然科学基金上面上项目的支持。
My key research, here at Dongfang hospital, has focused on investigating the optimization
of cancer treatment outcomes, in particular following hepatobiliary cancer surgery. And also, my research
works toward discovering the epigenetic molecular mechanisms of HBV related hepatocellular Carcinoma development. I have presided four projects on the National
Natural Science Foundation of China until now
Representative papers：
Guo T, Wang H, Liu P, Xiao Y, Wu P, Wang Y, Chen B, Zhao Q, Liu Z,
Liu
Q（通讯作者）. SNHG6 Acts
as a Genome-Wide Hypomethylation Trigger via Coupling of miR-1297-Mediated
S-Adenosylmethionine-Dependent Positive Feedback Loops. Cancer Res. 2018 Jul 15;78(14):3849-3864
Liu Q（通讯作者）.
Upregulation
of SNHG6 exhibits an oncogenic effect, regulating ZEB1 expression by
competitively binding miR-101-3p and interacting with UPF1 in hepatocellular
carcinoma. Cancer Letters. 2016 Oct 1. pii: S0304-3835(16)30590-0. doi: 10.1016/j.canlet.2016.09.034
Bi Y, Yu G, Liu Q（通讯作者）. Glucocorticoid-induced S-adenosylmethionine
Enhances the IFN Signaling Pathway by Restoring STAT1 Methylation in Hepatitis
B Virus Infected Cells. J Biol Chem. 2014
Sep 30. pii: jbc.M114.589689
Liu Q, Liu L, Zhao Y, Zhang J, Wang D, Chen J, He Y, Wu J, Zhang
Z, Liu Z Hypoxia induces
genomic DNA demethylation through the activation of HIF-1{alpha} and
transcriptional up-regulation of MAT2A in hepatoma cells.Mol Cancer Ther; 2011; 10(6): 1113–23 PMID:21460102
Liu Q, Chen J, Liu L, Zhang J, Wang D, Ma L, He Y, Liu Y, Liu Z, Wu
J.The X Protein of
Hepatitis B Virus Inhibits Apoptosis in Hepatoma Cells through Enhancing the
Methionine Adenosyltransferase 2A Gene Expression and Reducing
S-Adenosylmethionine Production. J Biol Chem.
2011 May 13;286(19):17168-80.
