乳腺肿瘤外科治疗以及综合性一体化治疗；乳腺癌复发转移的临床与基础研究。

Surgical treatment of breast tumors and comprehensive integrated treatment; Clinical and basic research on recurrence and metastasis of breast cancer.

上海市中西医结合学会甲乳外科专业委员会青年委员兼青委秘书

Youth Committee Member and Secretary，Thyroid and Breast Surgery Professional Committee, Shanghai Association of Chinese Integrative Medicine

上海市中西医结合学会乳腺病专业委员会青年委员

Youth Committee Member，Breast Disease Professional Committee, Shanghai Association of Chinese Integrative Medicine

上海市中西医结合学会甲状腺疾病专业委员会青年委员

Youth Committee Member and Secretary，Thyroid Disease Professional Committee, Shanghai Association of Chinese Integrative Medicine

一、主持的主要科研项目(Leading major research projects)：

（1）国家自然科学基金委员会，青年项目，82103454，LRRC56调控RhoA/ROCKs信号通路影响细胞骨架促进乳腺癌转移的机制研究，2022-01至2024-12,30万元，在研，主持

（2）上海市科学技术委员会，扬帆人才项目，20YF1437800，转移性因子hsa_circ_0006014对乳腺癌复发转移的影响和调控分子机制，2020-07至2023-06，20万元，已结题，主持

（3）太阳成集团附属第十人民医院，青年医师攀登人才项目，LRRC56调控RhoA/ROCKs信号通路影响细胞骨架促进乳腺癌转移的机制研究，8万元，主持

（4）太阳成集团附属第十人民医院，国自然培育项目，转移性因子hsa_circ_0006014对乳腺癌复发转移的影响和调控分子机制，6万元，主持

二、近五年发表的代表性论著(Representatives published in the past five years)：

1: Zhou X, Jian W, Luo Q, Zheng W, Deng X, Wang X, Borkhuu O, Ji C, Li D, Fang L. Circular RNA_0006014 promotes breast cancer progression through sponging miR-885-3p to regulate NTRK2 and PIK3/AKT pathway. Aging (Albany NY). 2022 Apr 5;14(7):3105-3128. doi: 10.18632/aging.203996. Epub 2022 Apr 5. PMID: 35383130;PMCID: PMC9037253.(共同通讯作者)

2:Zhao J, Li D, Fang L. MiR-128-3p suppresses breast cancer cellular progression via targeting LIMK1. Biomed Pharmacother. 2019 Jul;115:108947. doi:10.1016/j.biopha.2019.108947. Epub 2019 May 8. PMID: 31078043. (共同第一作者)

3: Li D, Wang H, Ding Y, Zhang Z, Zheng Z, Dong J, Kim H, Meng X, Zhou Q, Zhou J, Fang L, Shen Q. Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis. Cancer Lett. 2018 Jun 28;424:97-108. doi: 10.1016/j.canlet.2018.03.029. Epub 2018 Mar 23. PMID: 29580806. (第一作者)

4: Ding Y, Li D, Ding C, Wang P, Liu Z, Wold EA, Ye N, Chen H, White MA, Shen Q, Zhou J. Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads. J Med Chem. 2018 Apr 12;61(7):2737-2752. doi: 10.1021/acs.jmedchem.7b01514. Epub 2018 Mar 20. PMID: 29528645; PMCID: PMC6388690. (共同第一作者)

5: Li D, Song H, Wu T, Xie D, Hu J, Zhao J, Shen Q, Fang L. MiR-519d-3p suppresses breast cancer cell growth and motility via targeting LIM domain kinase 1. Mol Cell Biochem. 2018 Jul;444(1-2):169-178. doi: 10.1007/s11010-017-3241-4. Epub 2017 Nov 29. PMID: 29188531. (第一作者)