承担课题
1.国家自然科学基金-面上项目 PUM1调控胎盘滋养层细胞侵袭和增殖的机制研究 2021.01-2024.12 经费:55万,在研,主持
2.太阳成集团基本科研业务费项目-重点项目 Rabdosiin靶向表观遗传调控因子BAZ2B干预宫腔粘连疾病的探索性研究2024.04-2027.03经费:25万,在研,主持
3.国家自然基金委-青年项目Stathmin-1对母-胎界面滋养层细胞侵袭润性的调控作用及其分子机制研究 2015.01-2017.12 经费:23万,结题,主持
4.上海市科委-实验动物项目 基于人源性滋养层细胞模型在妊娠期环境危害物替代测试体系的研究 2020.07-2023.06 经费:20万,结题,主持
5.上海市卫计委-重点项目 转录因子YY1在复发性流产疾病中调控滋养层细胞浸润的临床及分子机理研究 2017.01-2019.12 经费:15万,结题,主持
6.上海市科委-面上项目 细胞骨架调控蛋白stathmin-1调控母-胎界面滋养层细胞浸润的分子机制研究2014-07至2017-07 经费:10万结题,主持
近5年发表论文
1.Xiao M, Zheng Y, Wang MX, Sun YH, Chen J, Zhu KY, Zhang F, Tang YH, Yang F, Zhou T, Zhang YP, Lei CX, Sun XX, Yu SH, Tian FJ*. Elevated histone demethylase KDM5C increases recurrent miscarriage risk by preventing trophoblast proliferation and invasion. Cell Death Discov. 2022 Dec 22;8(1):495.
2.Wei XW, Liu XQ, Zhang YC, Qin CM, Lin Y, Tian FJ*. TCF3 regulates human endometrial stromal cell proliferation and migration in RPL. Reproduction. 2022;163(5):281-291.
3.Zhang YC, Qin XL, Ma XL, Mo HQ, Qin S, Zhang CX, Wei XW, Liu XQ, Zhang Y, Tian FJ*, Lin Y*. CLDN1 regulates trophoblast apoptosis and proliferation in preeclampsia. Reproduction. 2021;161(6):623-632.
4.Zhang Y, He XY, Qin S, Mo HQ, Li X, Wu F, Zhang J, Li X, Mao L, Peng YQ, Guo YN, Lin Y, Tian FJ*. Upregulation of Pumilio 1 expression in preeclampsia impairs trophoblast invasion by negatively regulating the expression of the lncRNA HOTAIR. Mol Ther. 2020;28(2):631-641.
5. Li XC, Yin XJ, Hong W, Liu J, Jin F, Wang BY, Wang YM, Tian FJ*. The orphan nuclear receptor NUR77 promotes trophoblast invasion at early pregnancy through paracrine placental growth factor. J Mol Med (Berl). 2019;97(9): 1359-1373.
6.Li XC, Jin F, Wang BY, Yin XJ, Hong W, Tian FJ *. The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA. Theranostics 2019; 9: 3853-3865.