应用多能干细胞及类器官模型体外模拟女性生殖系统的生理和病理过程（包括卵巢和子宫的发育、胚胎植入过程以及卵巢早衰、子宫腺肌症、反复植入失败等疾病过程），研究其发育和发病机制，探索相关疾病治疗的新策略，并以此为基础开展细胞治疗及相关药物筛选的转化医学研究。

We focus on using human pluripotent stem cells and organoids to model the physiological and pathological processes of the female reproductive system in vitro (including ovarian and uterine development, embryo implantation process, the diseases of premature ovarian failure, adenomyosis, repeated implantation failure, etc.), study the developmental mechanisms and pathogenesis, and explore new strategies for disease treatment. On this basis, translational medicine research on cell therapy and related drug screening will be developed.

之前的研究主要聚焦在体细胞重编程的机制研究，发现多个可以促进体细胞重编程的卵源因子和表观遗传因子，并阐明其作用机制；同时，开展了女性生殖系统疾病相关的发病机制及细胞治疗工作。相关研究成果在Stem Cell Reports, Cell Porliferation等杂志上。结题或在研的国家自然科学基金项目2项。

Previously, we found several maternal and epigenetic factors can promoting somatic reprogramming and illustrated their mechanisms. Besides, we did researches of pathogenesis and cell therapy of female reproductive system diseases, including luteinized unruptured syndrome and premature ovarian failure. Some of the researches were published in the journals of Stem Cell Reports, Cell Proliferation. Two National Natural Science Foundation of China projects have been completed or under research.