生殖医学，生殖内分泌（包括多囊卵巢综合征，子宫内膜异位症，子宫肌腺症，卵巢低储备，反复种植失败），不孕症，辅助生殖相关技术

Reproductive medicine, reproductive endocrinology (including polycystic ovary syndrome, endometriosis, myoadenosis, low ovarian reserve, repeated implantation failure), infertility, assisted reproduction related technologies

太阳成集团附属上海市第一妇婴保健院辅助生殖科副主任

上海医学会生殖医学分会委员

中国优生科学协会生殖医学与生殖伦理学分会委员

上海市医师协会生殖医学分会委员。

Deputy director of Assisted Reproduction Department , Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University

Member of the Committee of Reproductive Medicine Branch of Shanghai Medical Association

Member of the Committee of Reproductive Medicine and Reproductive Ethics branch of China Healthy Birth Science Association

Member of the Committee of Reproductive Medicine Branch of Shanghai Medical Doctor Association.

主持科研项目：

1，脂肪组织细胞外囊泡联合透明质酸钠对子宫内膜修复作用的临床应用研究

上海市第一妇婴保健院院级；临床研究专项；重点项目；课题编号：2023B02；课题总经费：50万；起止时间：2023.12-2026.11； 主持，进行中

2，GnRH-1预处理超长方案与非预处理长方案对子宫体积＜12孕周或腺肌瘤＜6cm的子腺肌病患者IVF累积活产率的比较：一项RCT研究。

RCT注册号ChiCTR2300068876。

上海市浦东新区科技发展基金事业单位民生科研专项（医疗卫生）项目；项目编号：PKJ2022-Y16；直接经费：15万元；项目时间：2022.12-2024.11；区局级；主持，进行中

3，GnRH-a预处理的不同时间段对卵巢储备正常的子宫腺肌病患者IVF累积活产率的影响：一项RCT研究。

上海卫建委；面上项目；课题编号：202340111；课题总经费：10万；起止时间：2023.7.1-2026.6.30；主持，进行中

4，基于单分子荧光测序技术的流产物拷贝数变异检测

中国初级卫生保健基金会；课题编号：HY20227TUE11；费用：9万元；起止时间：2022.10-2025.9；主持，进行中

5，卵巢颗粒干细胞的分离培养

院级；2018人才项目；课题总经费：20万元；起止时间：2019.1-2020.12；主持

论文

[1] Zhi Qin Chen , Ai Ai , Yuan Zhang , He Li , Jing Yun Wang , Lu Wang , Ernest Hung Yu Ng  A randomized controlled trial to compare the live birth rate of the first frozen embryo transfer following the progestin-primed ovarian stimulation protocol vs. the antagonist protocol in women with an anticipated high ovarian response Fertil Steril. 2024 Jan 23:S0015-0282(24)00030-X. doi: 10.1016/j.fertnstert.2024.01.027. PMID: 38272383 DOI: 10.1016/j.fertnstert.2024.01.027

[2] Zhao Y., Zhao Y., Ai A., Jin L. Association of inactivated COVID-19 vaccination with in vitro fertilization and early pregnancy outcomes. J Med Virol. 2023;95(1):e28432.

[3] Wang L., Wang J., Zhang Y., Qian C., Wang X., Bai J., Li F., Chen Z., Ai A. Analysis of euploidy rates in preimplantation genetic testing for aneuploidy cycles with progestin-primed versus GnRH agonist/antagonist protocol. Eur J Med Res. 2023;28(1):28.

[4] Wang X., Ai A., Yu Z., Deng M., Liu W., Zhou G., Li W., Zhang W., Cao Y., Wang X. Dual-modal non-invasive imaging in vitro and in vivo monitoring degradation of PLGA scaffold based gold nanoclusters. Mater Sci Eng C Mater Biol Appl. 2020;107:110307.

[6] Chen M., Wu Y., Huang X., Li W., Sun C., Meng Z., Ai A., Hong L., Tang C., Li K., Fu Y., Chen Z., Kong P., Guo Y., Liu W., Mol B. W., Teng X. Embryo incubation by time-lapse systems versus conventional incubators in Chinese women with diminished ovarian reserve undergoing IVF/ICSI: a study protocol for a randomised controlled trial. BMJ Open. 2020;10(11):e038657.

[5] Ai A., Tang Z., Liu Y., Yu S., Li B., Huang H., Wang X., Cao Y., Zhang W. Characterization and identification of human immortalized granulosa cells derived from ovarian follicular fluid. Exp Ther Med. 2019;18(3):2167-77.

[6] Yu S., Long H., Chang H. Y., Liu Y., Gao H., Zhu J., Quan X., Lyu Q., Kuang Y., Ai A. New application of dydrogesterone as a part of a progestin-primed ovarian stimulation protocol for IVF: a randomized controlled trial including 516 first IVF/ICSI cycles. Hum Reprod. 2018;33(2):229-37.

[7] Chen Y., Ai A., Tang Z. Y., Zhou G. D., Liu W., Cao Y., Zhang W. J. Mesenchymal-like stem cells derived from human parthenogenetic embryonic stem cells. Stem Cells Dev. 2012;21(1):143-51.

[8] 艾爱, 陈瑶, 唐郑雅, 宋楠, 曹谊林, 张文杰. 诱导人孤雌胚胎干细胞向类间充质干细胞分化的实验研究. 组织工程与重建外科杂志. 2010. (03): 128-131.

[9] 艾爱, 吴红, 傅永伦，匡延平. IVF中输卵管性不孕是宫外孕的风险因素. 生殖与避孕. 2005. (06): 377-380.

[10] 艾爱, 吴红, 傅永伦，匡延平. 输卵管积水对体外受精-胚胎移植结局的影响. 上海医学. 2005. (07): 608-610.

[11] HE HUANG*, SHAOQING FENG*, WENJIE ZHANG, WEI LI, PENG XU, XIANGSHENG WANG and AI AI. Bone marrow mesenchymal stem cell‑derived extracellular vesicles improve the survival of transplanted fat grafts。MOLECULAR MEDICINE REPORTS 16: 3069-3078, 2017