1.肿瘤干细胞及表观遗传学调控在肿瘤发生与转移中的作用机制研究；2.妇科肿瘤精准诊疗及个体化治疗
1.Cancer stem cells and epigenetic regulation in tumor initiation and metastasis；2.Individualized diagnosis and treatment of gynecological tumors

太阳成集团转化医学高等研究院/附属第十人民医院 研究员Tongji University, Institute for Advanced Study/Shanghai Tenth People’s Hospital, Professor

1.主要以肿瘤干细胞自我更新核心特性为切入点，探讨肿瘤干细胞自我更新及其在肿瘤发生和转移中的作用机制，为肿瘤的临床肿瘤干细胞靶向治疗与个体化治疗提供理论支撑。2.采用二代测序,蛋白质组等组学技术研究妇科肿瘤分子分型，探索妇科肿瘤个体化治疗策略。相关研究成果在Gastroenterology、Journal of Hepatology、Clinical cancer research、Advanced Science 等期刊发表SCI论文7篇。累计主持省部级以上项目4项，获国家授权专利4项；上海市科技进步一等奖1项（2017）。上海市“青年科技启明星”（2019）。

Dr.Liu focus on investigating the underlying mechanism of the phenotype heterogeneity of CSCs and how CSCs promote tumor metastasis and also on investigating the subgroup of gynecological tumors with different molecular characters via omic-strategy such as Next generation sequencing, proteomic analysis for individualized diagnosis and treatment of gynecological tumors. To date, Dr.Liu has been published 7 papers in the high-profile international academic journals including GASTROENTEROLOGY、ADV SCI、J HEPATOL.

代表性论文：(1) Liu Shupeng#; Cheng Kai#; Zhang Hui; Kong Ruijiao; Wang Shuo; Mao Chuanbin*; Liu Shanrong*; Methylation Status of the Nanog Promoter Determines the Switch between Cancer Cells and Cancer Stem Cells, Advanced Science, 2020, 7(5): 201903035.1-11.

(2) Zhu, Yan#; Chen, Peizhan#; Gao, Yisha; Ta, Na; Zhang, Yunshuo; Cai, Jialin; Zhao, Yong; Liu, Shupeng*; Zheng, Jianming*; MEG3 Activated by Vitamin D Inhibits Colorectal Cancer Cells Proliferation and Migration via Regulating Clusterin , EBioMedicine, 2018, 30: 148-157.

(3) Guo Weixing#; Liu Shupeng#; Cheng Yuqiang#; Lu Lei; Shi Jie; Xu Guixia; Li Nan; Cheng Kai; Wu Mengchao; Cheng Shuqun*; Liu Shanrong*; ICAM-1-Related Noncoding RNA in Cancer Stem Cells Maintains ICAM-1 Expression in Hepatocellular Carcinoma , Clinical Cancer Research, 2016, 22(8): 2041-2050.

(4) Liu, Shupeng#; Li, Nan#; Yu, Xiya#; Xiao, Xiao; Cheng, Kai; Hu, Jingjing; Wang, Jiaqi; Zhang, Dandan; Cheng, Shuqun*; Liu, Shanrong*; Expression of Intercellular Adhesion Molecule 1 by Hepatocellular Carcinoma Stem Cells and Circulating Tumor Cells, GASTROENTEROLOGY, 2013, 144(5): 1031-1041.

(5) Liu, Shupeng#; Guo, Weixing#; Shi, Jie; Li, Nan; Yu, Xiya; Xue, Jie; Fu, Xiaohui; Chu, Kaijian; Lu, Chongde; Zhao, Jiangsha; Xie, Dong; Wu, Mengchao; Cheng, Shuqun*; Liu, Shanrong*; MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma, Journal of Hepatology, 2012, 56(2): 389-396.

(6) Liu, Shupeng#; Zhou, Zaixin#; Jia, Yin; Xue, Jie; Liu, Zhiyong; Cheng, Kai; Cheng, Shuqun; Liu, Shanrong*; Identification of portal vein tumor thrombus with an independent clonal origin in hepatocellular carcinoma via multi-omics data analysis , Cancer Biology & Medicine, 2019, 16(1): 147-170.

(7) Li Bin#; Zhu Yan#; Xie Lei; Hu Shuyang; Liu Shupeng*; Jiang Xiaoqing*; Portal vein ligation alters coding and noncoding gene expression in rat livers , Biochemistry and Cell Biology, 2018, 96(1): 1-10.