科研项目/Funding
1. 国家自然科学基金（National Natural Science Foundation of China），82072236，2021/01-2024/12，主持/PI
2. 国家自然科学基金（National Natural Science Foundation of China），81702037，2018/01-2020/12，主持/PI
3. 上海市“医苑新星”青年医学人才培养资助计划（Shanghai “Rising Stars of Medical Talent” Youth Development Program），2021-2024
4. 太阳成集团附属第十人民医院攀登人才计划（Pandeng Research Foundation of Shanghai Tenth People’s Hospital），2018SYPDRC015，2018/09-2020/08
发表论文/Publication
1. Bi D*, Zhu Y, Gao Y, Li H, Zhu X, Wei R, Xie R, Cai C, Wei Q, Qin H. Profiling Fusobacterium infection at high taxonomic resolution reveals lineage-specific correlations in colorectal cancer. Nature Communications. 2022, 13:3336
2. Zhu H#, Bi D#, Zhang Y#, Kong C#, Du J, Wu X, Wei Q, Qin H. Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations. Signal Transduction and Targeted Therapy, 2022, 7:11. (Review; # joint-first author)
3. Bi D, Zhu Y, Gao Y, Li H, Zhu X, Wei R, Xie R, Wei Q, Qin H. A newly developed PCR-based method revealed distinct Fusobacterium nucleatum subspecies infection patterns in colorectal cancer. Microbial Biotechnology, 2021, 14, 2176-2186.
4. Gao Y#, Bi D#, Xie R#, Li M, Guo J, Liu H, Guo X, Fang J, Ding T, Zhu H, Cao Y, Xing M, Zheng J, Xu Qing, Xu Qian, Wei Q, Qin H. Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer. Signal Transduction and Targeted Therapy, 2021, 6:398. (# joint-first author)
5. Cai C#, Bi D#, Bick G#, Wei Q, Liu H, Lu L, Zhang X, Qin H. HNF1A serves as a potential regulator in shaping super-enhancer landscape in colorectal cancer liver metastasis. FEBS Letters, 2021, 595:3056–3071. (# joint-first author)
6. Bi D, Zheng J, Xie R, Zhu Y, Wei R, Ou HY, Wei Q, Qin H. Comparative analysis of AbaR-type genomic islands reveals distinct patterns of genetic features in elements with different backbones. mSphere, 2020, 5:e00349-20.
7. Bi D, Xie R, Zheng J, Yang H, Ou HY, Wei Q. Large-scale identification of AbaR-type genomic islands in Acinetobacter baumannii reveals diverse insertion sites and clonal lineage-specific antimicrobial resistance gene profiles. Antimicrobial Agents and Chemotherapy, 2019, 63:e02526-18.
8. Bi D, Zheng J, Li JJ, Sheng ZK, Zhu X, Ou HY, Li Q, Wei Q. In silico typing and comparative genomic analysis of IncFIIK plasmids and insights into the evolution of replicons, plasmid backbones and resistance determinant profiles. Antimicrobial Agents and Chemotherapy, 2018, 62:e00764-18.
9. Dong X#, Bi D#, Wang H, Zou P, Xie G, Wan X, Yang Q, Zhu Y, Chen M, Guo C, Liu Z, Wang W, Huang J. pirABvp-Bearing Vibrio parahaemolyticus and Vibrio campbellii pathogens isolated from the same AHPND-affected pond possess highly similar pathogenic plasmids. Frontiers in Microbiology, 2017, 8:1859. (# joint-first author)
10. Bi D, Jiang X, Sheng ZK, Tai C, Wang M, Deng Z, Rajakumar K, Ou HY. Mapping the resistance-associated mobilome of a carbapenem-resistant Klebsiella pneumoniae strain reveals insights into factors shaping these regions and facilitates generation of a ‘resistance-disarmed’ model organism. Journal of Antimicrobial Chemotherapy, 2015, 70: 2770-4.
11. Li G#, Zhang Y#, Bi D#, Shen P, Ai F, Liu H, Tian Y, Ma Y, Wang B, Rajakumar K, Ou HY, Jiang X. First report of a clinical, multidrug-resistant Enterobacteriaceae isolate coharboring fosfomycin resistance gene fosA3 and cabarpenemase gene blaKPC-2 on the same transposon, Tn1721. Antimicrobial Agents and Chemotherapy, 2015, 59:338-343. (# joint-first author)
12. Bi D, Liu L; Tai C, Deng Z, Rajakumar K, Ou HY. SecReT4: a web-based bacterial type IV secretion system resource. Nucleic Acids Research, 2013, 41: D660-5.
13. Bi D, Xu Z, Harrison EM, Tai C, Wei Y, He X, Jia S, Deng Z, Rajakumar K, Ou HY. ICEberg: a web-based resource for integrative and conjugative elements found in Bacteria. Nucleic Acids Research, 2012, 40: D621-6.
14. Bi D, Chu D, Zhu P, Lu C, Fan C, Zhang J, Bao J. Utilization of dry distiller's grain and solubles as nutrient supplement in the simultaneous saccharification and ethanol fermentation at high solids loading of corn stover. Biotechnology Letters, 2011, 33: 273-276.
