麻醉药物毒性；麻醉与神经发育；中脑类器官；器官芯片；

Toxicity of anesthetic drugs; Anesthesia and neurodevelopment; Midbrain organoid; Organ chip

国务院政府特殊津贴获得者；黄石市政协委员；国家自然科学基金评审专家；湖北省“百人计划”获得者；湖北省有突出贡献中青年专家；湖北省临床重点专科麻醉科主任；浦东新区卫生高层次人才“B”类；浦东新区新质学科带头人；湖北省医学青年拔尖人才；黄石市有突出贡献中青年专家；黄石市十大杰出青年；

中国老年医学会麻醉学分会委员；，湖北黄石市麻醉学专业委员会主任委员；中国医师学会结直肠委员会围术期专委会委员；中国心胸麻醉学会舒适化医疗分会委员；湖北省医学会麻醉学分会委员；湖北省医师协会麻醉学分会委员；

Recipient of the State Council Government Special Allowance; Member of the Political Consultative Conference of Huangshi City; National Natural Science Foundation of China evaluation expert; Recipient of the "Hundred Talents Program" in Hubei Province; Young and middle-aged experts with outstanding contributions in Hubei Province; Director of Anesthesiology Department of Clinical Key Specialty in Hubei Province; Pudong New District High level Health Talents "Category" B; Leader of New Quality Discipline in Pudong New District; Top young medical talents in Hubei Province; Young and middle-aged experts with outstanding contributions in Huangshi City; Top Ten Outstanding Young Persons in Huangshi City;

Member of the Anesthesiology Branch of the Chinese Geriatric Society;, Chairman of the Anesthesiology Professional Committee of Huangshi City, Hubei Province; Member of the Perioperative Committee of the Colorectal Committee of the Chinese Medical Association; Member of the Comfort Medicine Branch of the Chinese Society of Cardiothoracic Anesthesia; Member of the Anesthesiology Branch of Hubei Medical Association; Member of the Anesthesiology Branch of Hubei Medical Association;

科研项目

1： 国家自然科学基金面上项目：非长链编码RNA-LIN在七氟烷引起的社会交往障碍中的机制研究 项目编号：81870855，课题负责人 2019年

2: 国家自然科学基金： 七氟醚通过miRNA218-NF-κB信号通路调节胚胎干细胞向神经元分化的分子机制研究 项目编号：U1404808，课题负责人 2014年，已经结题。

3：湖北省自然科学基金：七氟烷通过GABAA-Sirt1对孕早期胚胎神经系统发育的影响 项目编号：2016CFB441，课题负责人 2016年,已经结题。

4: 江西省科技厅青年科学基金资助项目计划：脑源性神经营养因子及其前体对切割疼痛影响的机制 项目编号：20114BAB215007 ，课题负责人

5: 江西省教育厅青年科学基金资助项目计划：脑源性神经营养因子及其前体对疼痛影响的机制 项目编号：GJJ12157，课题负责人

发表第一/通讯作者SCI文章

1 Yang Huan, Shi Xiaoling, Li Jinping, Yang Longqiu.Efficacy and safety of alfentanil plus propofol versus propofol only in painless gastrointestinal endoscopy A meta-analysis. Medicine.102(32)1-8.2023.（通讯作者，IF值1.6）

2 Shang Jia, Li Bin, Fan Han, Liu Peidi, Zhao Wen, Chen Tao, Chen Pu,Yang Longqiu. Sevoflurane promotes premature differentiation of dopaminergic neurons in hiPSC-derived midbrain organoids. Frontiers in Cell and Developmental Biology.10:1-6.2022.（通讯作者，IF值6.081）

3 Bao Xian, Peng Yibo, Shen Jun, Yang Longqiu. Sevoflurane inhibits progression of glioma via regulating the HMMR antisense RNA 1/microRNA-7/cyclin dependent kinase 4 axis.Bioengineered.12(1), 7893–7906. 2021. （通讯作者，IF值3.62）

4 Yang Longqiu, He Ke, Yao Shudong,Zhang Yiqiang,Shen Jun.Sevoflurane inhibits neuroblastoma cell proliferation and invasion and induces apoptosis by miR-144-3p/YAP1 axis.Basic Clin Pharmacol Toxicol.129(4):297-307. 2021. （第一作者，IF值4.08）

5 Yang Longqiu, Luo Pengcheng, Song Qiong, Fei Xuejie. DNMT1/miR-200a/GOLM1 signaling pathway regulates lung adenocarcinoma cells proliferation. Biomed Pharmacother. 99:839-847. 2018. （第一作者，IF值3.492）

6 Yang Longqiu, Luo Pengcheng, Fei Xuejie, Zhang Peng. A miRNAs panel promotes the proliferation and invasion of colorectal cancer cells by targeting GABBR1. Cancer Medicine. 5(8), 2022-2031. 2016. （第一作者，IF值2.9）

7 Qiong Song, Song Jiangqiang, Wang Qimin, Ma Yanling, Sun Nai, Ma Jieyu, Chen Qiu, Xia Guishan, Huo Yanping, Yang Longqiu, Li Baolin. miR-548d-3p/TP53BP2 axis regulates the proliferation and apoptosis of breast cancer cells. Cancer Medicine. 5(2), 315-324. 2015. （共同通讯作者，IF值2.9）

8 Liu Sheng, Zhang Lei, Liu Yi, Shen Xia, Yang Longqiu*.Isoflurane inhibits embryonic stem cell self-renewal through retinoic acid receptor. Biomed Pharmacother. 74, 111-116. 2015. （通讯作者，IF值3.492）

9 Wang Qingxiu, Zhao Yupeng, Sun Min, Liu Sheng, Li Baolin, Zhang Lei, Yang Longqiu*. 2-deoxy-D-glucose attenuates sevoflurane-induced neuroinflammation through nuclear factor-kappa B pathway in vitro. Toxicology in Vitro. 28, 1183-1189. 2014.（通讯作者，IF值3.21）

10 Yang Longqiu, Xin Xin, Zhang Jie, Zhang Lei, Dong Yuanlin, Zhang Yiying, Mao Jianren, Xie zhongcong*. Inflammatory Pain May Induce Cognitive Impairment Through an IL-6 Dependent and PSD-95-Associated Mechanism. Anesthesia & Analgesia. 119, 471-480. 2014. (第一作者，IF值3.463）

11 He Gengsheng., Zhang Lei, Li Qing*, Yang Longqiu*. miR-92a/DUSP10/JNK signaling axis promotes human pancreastic cancer cells proliferation.Biomed Pharmacother. 68, 25-30. 2013. （通讯作者，IF值3.492）

12 Yang Longqiu, Li Qing, Wang Qingxiu, Jiang Zhen, Zhang Lei*. Silencing of miRNA-218 promotes migration and invasion of breast cancer via Slit2-Robo1 pathway.Biomed Pharmacother. 66, 535-540. 2012. （第一作者，IF值3.492）

13 Yang Longqiu, Tang ZhengGuo. Isoflurane inhibits embryonic stem cell and induces pluripotent stem cell self-renewal by down-regulation of E-cadherin. British Journal of Anaesthesia. 113(6), 1068-1070, 2014. (BJA摘要，第一作者 IF值 4.35)

所获奖项

Longqiu Yang, Lei Zhang, Guorong Tao, Yuanlin Dong, Yiying Zhang and Zhongcong Xie Inflammatory pain induces cognitive impairment through an IL-6-dependent and PSD95-associated mechanism 美国2013年麻醉年会best abstracts（basic research：top 6）

Research Projects

1: National Natural Science Foundation of China General Project: Mechanism Study of Non Long Chain Coding RNA-LIN in Social Interaction Disorders Induced by Sevoflurane. Project Number: 81870855. Project Leader. 2019

2: National Natural Science Foundation of China: Molecular Mechanism of Sevoflurane Regulating the Differentiation of Embryonic Stem Cells into Neurons through miRNA218-NF-κ B Signaling Pathway. Project Number: U1404808. Project Leader. 2014. completed.

3: Hubei Provincial Natural Science Foundation: The Effects of Sevoflurane on Early Embryonic Neurological Development through GABAA-Sirt1. Project Number: 2016CFB441. Project Leader. 2016. completed

4: Project funded by the Youth Science Fund of Jiangxi Provincial Department of Science and Technology: Mechanisms of the Effects of Brain Derived Neurotrophic Factors and Their Precursors on Cutting Pain. Project Number: 20114BAB21500. Project Leader

5: Project funded by the Youth Science Fund of the Education Department of Jiangxi Province: Mechanisms of the Effects of Brain Derived Neurotrophic Factors and Their Precursors on Pain. Project Number: GJJ12157. Project Leader

Publish first/corresponding author SCI article

1 Yang Huan, Shi Xiaoling, Li Jinping, Yang Longqiu.Efficacy and safety of alfentanil plus propofol versus propofol only in painless gastrointestinal endoscopy A meta-analysis. Medicine.102(32)1-8.2023.（Corresponding author，IF:1.6）

2 Shang Jia, Li Bin, Fan Han, Liu Peidi, Zhao Wen, Chen Tao, Chen Pu,Yang Longqiu. Sevoflurane promotes premature differentiation of dopaminergic neurons in hiPSC-derived midbrain organoids. Frontiers in Cell and Developmental Biology.10:1-6.2022.（Corresponding author，IF:值6.081）

3 Bao Xian, Peng Yibo, Shen Jun, Yang Longqiu. Sevoflurane inhibits progression of glioma via regulating the HMMR antisense RNA 1/microRNA-7/cyclin dependent kinase 4 axis.Bioengineered.12(1), 7893–7906. 2021. （Corresponding author，IF:3.62）

4 Yang Longqiu, He Ke, Yao Shudong,Zhang Yiqiang,Shen Jun.Sevoflurane inhibits neuroblastoma cell proliferation and invasion and induces apoptosis by miR-144-3p/YAP1 axis.Basic Clin Pharmacol Toxicol.129(4):297-307. 2021. （First author，IF:4.08）

5 Yang Longqiu, Luo Pengcheng, Song Qiong, Fei Xuejie. DNMT1/miR-200a/GOLM1 signaling pathway regulates lung adenocarcinoma cells proliferation. Biomed Pharmacother. 99:839-847. 2018. （First author，IF:3.492）

6 Yang Longqiu, Luo Pengcheng, Fei Xuejie, Zhang Peng. A miRNAs panel promotes the proliferation and invasion of colorectal cancer cells by targeting GABBR1. Cancer Medicine. 5(8), 2022-2031. 2016. （First author，IF:2.9）

7 Qiong Song, Song Jiangqiang, Wang Qimin, Ma Yanling, Sun Nai, Ma Jieyu, Chen Qiu, Xia Guishan, Huo Yanping, Yang Longqiu, Li Baolin. miR-548d-3p/TP53BP2 axis regulates the proliferation and apoptosis of breast cancer cells. Cancer Medicine. 5(2), 315-324. 2015. （Corresponding author，IF:2.9）

8 Liu Sheng, Zhang Lei, Liu Yi, Shen Xia, Yang Longqiu*.Isoflurane inhibits embryonic stem cell self-renewal through retinoic acid receptor. Biomed Pharmacother. 74, 111-116. 2015. （Corresponding author，IF:3.492）

9 Wang Qingxiu, Zhao Yupeng, Sun Min, Liu Sheng, Li Baolin, Zhang Lei, Yang Longqiu*. 2-deoxy-D-glucose attenuates sevoflurane-induced neuroinflammation through nuclear factor-kappa B pathway in vitro. Toxicology in Vitro. 28, 1183-1189. 2014.（Corresponding author，IF:3.21）

10 Yang Longqiu, Xin Xin, Zhang Jie, Zhang Lei, Dong Yuanlin, Zhang Yiying, Mao Jianren, Xie zhongcong*. Inflammatory Pain May Induce Cognitive Impairment Through an IL-6 Dependent and PSD-95-Associated Mechanism. Anesthesia & Analgesia. 119, 471-480. 2014. (First author，IF:3.463）

11 He Gengsheng., Zhang Lei, Li Qing*, Yang Longqiu*. miR-92a/DUSP10/JNK signaling axis promotes human pancreastic cancer cells proliferation.Biomed Pharmacother. 68, 25-30. 2013. （Corresponding author，IF:3.492）

12 Yang Longqiu, Li Qing, Wang Qingxiu, Jiang Zhen, Zhang Lei*. Silencing of miRNA-218 promotes migration and invasion of breast cancer via Slit2-Robo1 pathway.Biomed Pharmacother. 66, 535-540. 2012. （First author，IF:3.492）

13 Yang Longqiu, Tang ZhengGuo. Isoflurane inhibits embryonic stem cell and induces pluripotent stem cell self-renewal by down-regulation of E-cadherin. British Journal of Anaesthesia. 113(6), 1068-1070, 2014. (BJA Abstract，First author IF: 4.35)

Awards received

Longqiu Yang, Lei Zhang, Guorong Tao, Yuanlin Dong, Yiying Zhang and Zhongcong Xie.Inflammatory pain induces cognitive impairment through an IL-6-dependent and PSD95-associated mechanism. 2013 Anesthesia Annual Meeting in the United States. best abstracts（basic research：top 6）